TY - JOUR
T1 - Structure modification of ethyl p-methoxycinnamate and their bioassay as chemopreventive agent against mice's fibrosarcoma
AU - Ekowati, Juni
AU - Tejo, Bimo A.
AU - Sasaki, Shigeru
AU - Highasiyama, Kimio
AU - Sukardiman,
AU - Siswandono,
AU - Budiati, Tutuk
PY - 2012
Y1 - 2012
N2 - In the present study, ethyl p-methoxycinnamate isolated from Kaempferia galanga was used as starting material to produce thiourea derivatives (4a, 4b, 4c) in a good yield. The synthesis products were confirmed by FTIR, 1H-NMR, 13C-NMR and HRMS spectroscopic methods. Their activities against fibrosarcoma were tested in vivo using mouse model induced by 0.3% benzo(a)pyrene injected subcutaneously, which was given five times, once every two days. Our results showed that fibrosarcoma can be inhibited by all synthesized compounds. In silico analysis predicted that one of mechanism chemopreventive activity of all synthesized compounds against fibrosarcoma through inhibition of COX-2.
AB - In the present study, ethyl p-methoxycinnamate isolated from Kaempferia galanga was used as starting material to produce thiourea derivatives (4a, 4b, 4c) in a good yield. The synthesis products were confirmed by FTIR, 1H-NMR, 13C-NMR and HRMS spectroscopic methods. Their activities against fibrosarcoma were tested in vivo using mouse model induced by 0.3% benzo(a)pyrene injected subcutaneously, which was given five times, once every two days. Our results showed that fibrosarcoma can be inhibited by all synthesized compounds. In silico analysis predicted that one of mechanism chemopreventive activity of all synthesized compounds against fibrosarcoma through inhibition of COX-2.
KW - Cyclooxygenase-2
KW - Ethyl p-methoxycinnamate
KW - Fibrosarcoma
KW - Kaempferia galanga
KW - Thiourea derivatives
UR - http://www.scopus.com/inward/record.url?scp=84862624442&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84862624442
SN - 0975-1491
VL - 4
SP - 528
EP - 532
JO - International Journal of Pharmacy and Pharmaceutical Sciences
JF - International Journal of Pharmacy and Pharmaceutical Sciences
IS - SUPPL.3
ER -