Structure modification of ethyl p-methoxycinnamate and their bioassay as chemopreventive agent against mice's fibrosarcoma

Juni Ekowati, Bimo A. Tejo, Shigeru Sasaki, Kimio Highasiyama, Sukardiman, Siswandono, Tutuk Budiati

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

In the present study, ethyl p-methoxycinnamate isolated from Kaempferia galanga was used as starting material to produce thiourea derivatives (4a, 4b, 4c) in a good yield. The synthesis products were confirmed by FTIR, 1H-NMR, 13C-NMR and HRMS spectroscopic methods. Their activities against fibrosarcoma were tested in vivo using mouse model induced by 0.3% benzo(a)pyrene injected subcutaneously, which was given five times, once every two days. Our results showed that fibrosarcoma can be inhibited by all synthesized compounds. In silico analysis predicted that one of mechanism chemopreventive activity of all synthesized compounds against fibrosarcoma through inhibition of COX-2.

Original languageEnglish
Pages (from-to)528-532
Number of pages5
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume4
Issue numberSUPPL.3
Publication statusPublished - 2012

Keywords

  • Cyclooxygenase-2
  • Ethyl p-methoxycinnamate
  • Fibrosarcoma
  • Kaempferia galanga
  • Thiourea derivatives

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