TY - JOUR
T1 - Stress ulcer prophylaxis in patients with brain injury
T2 - Retrospective study
AU - Hutahaean, Yuliaty Retta
AU - Sumarno,
AU - Wahyuhadi, Joni
AU - Padolo, Elfi
N1 - Publisher Copyright:
© 2019, Indian Journal of Public Health Research and Development. All rights reserved.
PY - 2019/7
Y1 - 2019/7
N2 - Background: Brain injury is one of the risk factors for stress ulcers. As many as 52% of brain injury patients use inappropriate prophylaxis, this can result in gastrointestinal bleeding and may lead to death. Until now the most widely used type of prophylaxis is the H2-Antagonist receptor, Proton Pump Inhibitor (PPI) and sucralfate. Objective: This study aims to determine the use of stress ulcer prophylaxis in patients with brain injury. Method: Retrospective study with 43 data of patients with brain injury. The data on stress ulcer prophylaxis during the patient’s hospitalization are collected. Results: There are 3 types of prophylaxis used, namely H2-Antagonists, PPIs, and Sucralfates. The most widely used type is H2-Antagonist, which is 85.7%. The next drugs were PPI by 10.39% and sucralfate by 3.90%. The route of administration is mostly through oral administration of ranitidine as much as 93.5%. Therapy can be given in single drug or in a combination. Conclusion: The type of drug used for stress ulcer prophylaxis in patients with brain injury is H2-Antagonists, PPIs and Sucralfate. Prophylactic therapy can be given in single drug or in combination. The administration of omeprazole affected the performance of phenytoin and diazepam.
AB - Background: Brain injury is one of the risk factors for stress ulcers. As many as 52% of brain injury patients use inappropriate prophylaxis, this can result in gastrointestinal bleeding and may lead to death. Until now the most widely used type of prophylaxis is the H2-Antagonist receptor, Proton Pump Inhibitor (PPI) and sucralfate. Objective: This study aims to determine the use of stress ulcer prophylaxis in patients with brain injury. Method: Retrospective study with 43 data of patients with brain injury. The data on stress ulcer prophylaxis during the patient’s hospitalization are collected. Results: There are 3 types of prophylaxis used, namely H2-Antagonists, PPIs, and Sucralfates. The most widely used type is H2-Antagonist, which is 85.7%. The next drugs were PPI by 10.39% and sucralfate by 3.90%. The route of administration is mostly through oral administration of ranitidine as much as 93.5%. Therapy can be given in single drug or in a combination. Conclusion: The type of drug used for stress ulcer prophylaxis in patients with brain injury is H2-Antagonists, PPIs and Sucralfate. Prophylactic therapy can be given in single drug or in combination. The administration of omeprazole affected the performance of phenytoin and diazepam.
KW - Brain injury
KW - H2-antagonist
KW - PPI
KW - Stress ulcer prophylaxis
UR - http://www.scopus.com/inward/record.url?scp=85070740990&partnerID=8YFLogxK
U2 - 10.5958/0976-5506.2019.01347.0
DO - 10.5958/0976-5506.2019.01347.0
M3 - Article
AN - SCOPUS:85070740990
SN - 0976-0245
VL - 10
SP - 631
EP - 636
JO - Indian Journal of Public Health Research and Development
JF - Indian Journal of Public Health Research and Development
IS - 6
ER -