Stress ulcer prophylaxis in patients with brain injury: Retrospective study

Yuliaty Retta Hutahaean, Sumarno, Joni Wahyuhadi, Elfi Padolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Brain injury is one of the risk factors for stress ulcers. As many as 52% of brain injury patients use inappropriate prophylaxis, this can result in gastrointestinal bleeding and may lead to death. Until now the most widely used type of prophylaxis is the H2-Antagonist receptor, Proton Pump Inhibitor (PPI) and sucralfate. Objective: This study aims to determine the use of stress ulcer prophylaxis in patients with brain injury. Method: Retrospective study with 43 data of patients with brain injury. The data on stress ulcer prophylaxis during the patient’s hospitalization are collected. Results: There are 3 types of prophylaxis used, namely H2-Antagonists, PPIs, and Sucralfates. The most widely used type is H2-Antagonist, which is 85.7%. The next drugs were PPI by 10.39% and sucralfate by 3.90%. The route of administration is mostly through oral administration of ranitidine as much as 93.5%. Therapy can be given in single drug or in a combination. Conclusion: The type of drug used for stress ulcer prophylaxis in patients with brain injury is H2-Antagonists, PPIs and Sucralfate. Prophylactic therapy can be given in single drug or in combination. The administration of omeprazole affected the performance of phenytoin and diazepam.

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalIndian Journal of Public Health Research and Development
Volume10
Issue number6
DOIs
Publication statusPublished - Jul 2019

Keywords

  • Brain injury
  • H2-antagonist
  • PPI
  • Stress ulcer prophylaxis

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