Stimulation of Dental Socket Healing by Pangasius Djambal Gelatin: Evaluation of Growth Factor Expression

Varellia A.W. Kardikadewi, Fredy Mardiyantoro, Nenny Prasetyaningrum, Lukman H. Hidayat, Dwika H. Andriani, Savira P. Dianti, Taufan Bramantoro

Research output: Contribution to journalArticlepeer-review


Introduction: Growth factors play a lot of roles in the process of wound healing following tooth extraction. The effect of Pangasius djambal gelatin on expression and pattern of distribution of these growth factors have not been investigated in early phase of wound healing after tooth extraction. This study aimed to observe the pattern of distribution of growth factors in dental socket healing of albino rats (Rattus norvegicus) following tooth extraction. Methods: 24 albino rats were used as an experimental method with randomized posttest-only control group design. Treatment groups were treated with P. djambal gelatin after tooth extraction, while control groups were left untreated after tooth extraction. The present immunohistochemical study used polyclonal antibodies specific for Platelet-Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor-2 (FGF-2), and Epidermal Growth Factor (EGF). Results: There was a statistically significant increase of PDGF, VEGF, FGF-2, and EGF expression in the treatment groups compared with the control groups. Conclusion: The application of P. djambal gelatin to dental socket post tooth extraction could increase the level of growth factors expression during dental socket healing process.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalMalaysian Journal of Medicine and Health Sciences
Publication statusPublished - Apr 2023


  • Gelatin
  • Growth factor
  • Pangasius djambal
  • Tooth extraction
  • Wound healing


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