Some benzoxazine and aminomethyl derivatives of eugenol: Cytotoxicity on MCF-7 cell line

Objective: The objective of this research is to examine in vitro cytotoxicity of some benzoxazine and aminomethyl derivatives of eugenol against the MCF-7 cancer cell line. Methods: 6-Allyl-8-methoxy-3-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine, 6-allyl-3-benzyl-8-methoxy-3,4-dihydro-2H-benzo[e][1,3]oxazine, 6-allyl-3-(furan-2-ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo[e][1,3]oxazine, 4-allyl-2-methoxy-6-(phenylaminomethyl)phenol, 4-allyl-2-(benzylaminomethyl)-6-methoxyphenol, and 4-allyl-2-{[(furan-2-ylmethyl)amino]methyl}-6-methoxyphenol were subjected to cytotoxicity study using MTT assay and calculate the percent of cell viability. Results: The obtained LC50 values of the tested compounds on MCF-7 cancer cell line are respectively 96.9±6.84, 26.4±2.68, 21.7±2.90, 58.4±4.42, 29.2±2.39, and 45.7±4.62 mg/ml. Conclusion: All the tested compounds have cytotoxicity against the MCF-7 cell line.