TY - GEN
T1 - Solute diffusion through the fibrotic tissue formed around a protective cage system for implantable sensors
AU - Ito, Hikaru
AU - Prihandana, Gunawan Setia
AU - Tanimura, Kohei
AU - Hori, Yuki
AU - Soykan, Orhan
AU - Sudo, Ryo
AU - Miki, Norihisa
PY - 2012
Y1 - 2012
N2 - Biocompatible packaging is crucial in developing implantable sensors. It should allow solutes of interest to diffuse through while minimizing inflammatory response to the packaging and the sensors. In this study, a cage system made of a metal mesh cylinder surrounded by a polyvinyl alcohol (PVA) sponge material was implanted into rats, and fibrotic tissue was formed around the cage system. We then experimentally investigated the permeation rate of solutes (Na, K and Cl) through the fibrotic tissue using a microfluidic device, and found that diffusion coefficients with respect to all the solutions were on the order of 10-10 m2/s, which increased with the flow rates.
AB - Biocompatible packaging is crucial in developing implantable sensors. It should allow solutes of interest to diffuse through while minimizing inflammatory response to the packaging and the sensors. In this study, a cage system made of a metal mesh cylinder surrounded by a polyvinyl alcohol (PVA) sponge material was implanted into rats, and fibrotic tissue was formed around the cage system. We then experimentally investigated the permeation rate of solutes (Na, K and Cl) through the fibrotic tissue using a microfluidic device, and found that diffusion coefficients with respect to all the solutions were on the order of 10-10 m2/s, which increased with the flow rates.
KW - Biocompatible packaging
KW - Diffusion
KW - Fibrotic tissue
UR - http://www.scopus.com/inward/record.url?scp=84901748599&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84901748599
SN - 9780979806452
T3 - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
SP - 1267
EP - 1269
BT - Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PB - Chemical and Biological Microsystems Society
T2 - 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Y2 - 28 October 2012 through 1 November 2012
ER -