Solubility, dissolution test and antimalarial activity of artesunate nicotinamide co-crystal prepared by solvent evaporation and slurry methods

Dwi Setyawan, Narendra Kusuma Wardhana, Retno Sari

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The aims of this study was to investigate the solubility, dissolution rate and antimalarial activity against Plasmodium berghei of artesunate (AR)-nicotinamide co-crystal prepared by solvent evaporation (CoSE) and slurry (CoS) method. Methods: Co-crystals of AR-nicotinamide prepared by solvent evaporation and slurry methods were tested for solubility, dissolution rate and activity of antimalarial compared to pure AR and physical mixture (PM) of AR and nicotinamide. Solubility test was conducted in distilled water at 37±0.5°C and dissolution test was done in distilled water medium at 37±0.5°C using paddle stirrer. Antimalarial activity test was carried out on female mice infected by P. berghei then parasitemia was observed. Results: The AR solubility of slightly increased from 1236.66±141.42 to 1368.46±49.17 mg/L. Dissolution data at 30 minutes respectively for AR, PM, CoS and CoSE (76.51±14.93; 75.45±18.07; 85.14±12.94 and 123.24±7.68%). The results were antimalarial activity test of P. berghei showed that percent inhibition 84.98-89.50%. These data showed no significant differences in antimalarial activity between AR, CoS and CoSE. Conclusions: Co-crystal AR nicotinamide prepared by solvent evaporation and slurry methods could increase the dissolution rate of AR in distilled water medium compared to pure AR. Co-crystal AR nicotinamide prepared by solvent evaporation was not significant difference as antimalarial activity in P. berghei compared to pure AR.

Original languageEnglish
Pages (from-to)164-166
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume8
Issue number2
Publication statusPublished - 1 Mar 2015

Keywords

  • Antimalarial activity
  • Artesunate
  • Co-crystal
  • Dissolution rate
  • Nicotinamide
  • Slurry method
  • Solvent evaporation method

Fingerprint

Dive into the research topics of 'Solubility, dissolution test and antimalarial activity of artesunate nicotinamide co-crystal prepared by solvent evaporation and slurry methods'. Together they form a unique fingerprint.

Cite this