Socs (Suppressor of cytokine signaling) protein as material to enhance the effect of growth hormone in broilers

Anwar Ma’Ruf, L. Nunuk Dyah Retno, Ratna Damayanti, Nove Hidajati, M. Gandul Atik

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to identify specific proteins that can slow down the SOCS protein activity in STAT signaling protein termination so that it will induce the increase in GH metabolic effect in enhancing the growth of broilers and their meat quality. It is, therefore, necessary to identify the molecular weight and the composition of the SOCS (Suppressor of Cytokine Signaling) protein acid that act in the signaling of STAT (Signal Transducers and Activators of Transcription) activated by GH (Growth Hormone) in broilers. By identifying the molecular weight and the composition of the amino acids of SOCS proteins, there is a great chance to make a specific protein that can slow down the SOCS protein activity in STAT signaling protein termination. Therefore, there is an increase in GH metabolic effect in enhancing the broilers’ growth and their meat quality. The results indicated that SOCS-1 protein was present in broilers’ liver tissue. An examination with Western Blot noted that the molecular weight of the SOCS-1 protein was 98 kDa. This finding signifies that SOCS-1 protein is a protein that serves as negative feedback on broiler growth through growth hormone.

Original languageEnglish
Pages (from-to)701-705
Number of pages5
JournalEurAsian Journal of BioSciences
Volume13
Issue number2
Publication statusPublished - 1 Aug 2019

Keywords

  • Broiler
  • Growth
  • Growth hormone
  • Protein SOCS

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