Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma

Fumi Tanaka; Andra Rizqiawan; Koichiro Higashikawa; Kei Tobiume; Gaku Okui; Hideo Shigeishi; Shigehiro Ono; Hiroshi Shimasue; Nobuyuki Kamata

doi:10.1016/j.canlet.2012.11.023

Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma

Fumi Tanaka, Andra Rizqiawan, Koichiro Higashikawa, Kei Tobiume, Gaku Okui, Hideo Shigeishi, Shigehiro Ono, Hiroshi Shimasue, Nobuyuki Kamata

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We previously identified genes associated with Snail-mediated squamous cell carcinoma (SCC) invasiveness, in which we observed significant elevation of Cyr61 expression. In this study, SCC cell lines overexpressing Cyr61 exhibited constitutive activation of Rho A and upregulated invasiveness without the disruption of homophilic cell attachment. Humoral Cyr61 enhanced further production of endogenous Cyr61 by SCC cells, which stimulated collective cell migration and the development of an invasive tumor nest. We propose a Cyr61-dependent model for the development of invasive SCC nest, whereby a subset of tumor cells that highly produce Cyr61 may direct other tumor cells to undergo collective cell migration, resulting in a formation of primary SCC mass.

Original language	English
Pages (from-to)	243-252
Number of pages	10
Journal	Cancer Letters
Volume	329
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.11.023
Publication status	Published - 28 Feb 2013
Externally published	Yes

Keywords

Cyr61
EMT
Snail
Squamous cell carcinoma
Tumor invasion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.11.023

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title = "Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma",

abstract = "We previously identified genes associated with Snail-mediated squamous cell carcinoma (SCC) invasiveness, in which we observed significant elevation of Cyr61 expression. In this study, SCC cell lines overexpressing Cyr61 exhibited constitutive activation of Rho A and upregulated invasiveness without the disruption of homophilic cell attachment. Humoral Cyr61 enhanced further production of endogenous Cyr61 by SCC cells, which stimulated collective cell migration and the development of an invasive tumor nest. We propose a Cyr61-dependent model for the development of invasive SCC nest, whereby a subset of tumor cells that highly produce Cyr61 may direct other tumor cells to undergo collective cell migration, resulting in a formation of primary SCC mass.",

keywords = "Cyr61, EMT, Snail, Squamous cell carcinoma, Tumor invasion",

author = "Fumi Tanaka and Andra Rizqiawan and Koichiro Higashikawa and Kei Tobiume and Gaku Okui and Hideo Shigeishi and Shigehiro Ono and Hiroshi Shimasue and Nobuyuki Kamata",

note = "Funding Information: We would like to thank our colleagues at Department of Oral and Maxillofacial Surgery for their support in accomplishing this study. This work was supported by a Grant-in-aid from the Japanese Ministry of Education, Culture, Sports, Science and Technology. ",

year = "2013",

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day = "28",

doi = "10.1016/j.canlet.2012.11.023",

language = "English",

volume = "329",

pages = "243--252",

journal = "Cancer Letters",

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TY - JOUR

T1 - Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma

AU - Tanaka, Fumi

AU - Rizqiawan, Andra

AU - Higashikawa, Koichiro

AU - Tobiume, Kei

AU - Okui, Gaku

AU - Shigeishi, Hideo

AU - Ono, Shigehiro

AU - Shimasue, Hiroshi

AU - Kamata, Nobuyuki

N1 - Funding Information: We would like to thank our colleagues at Department of Oral and Maxillofacial Surgery for their support in accomplishing this study. This work was supported by a Grant-in-aid from the Japanese Ministry of Education, Culture, Sports, Science and Technology.

PY - 2013/2/28

Y1 - 2013/2/28

N2 - We previously identified genes associated with Snail-mediated squamous cell carcinoma (SCC) invasiveness, in which we observed significant elevation of Cyr61 expression. In this study, SCC cell lines overexpressing Cyr61 exhibited constitutive activation of Rho A and upregulated invasiveness without the disruption of homophilic cell attachment. Humoral Cyr61 enhanced further production of endogenous Cyr61 by SCC cells, which stimulated collective cell migration and the development of an invasive tumor nest. We propose a Cyr61-dependent model for the development of invasive SCC nest, whereby a subset of tumor cells that highly produce Cyr61 may direct other tumor cells to undergo collective cell migration, resulting in a formation of primary SCC mass.

AB - We previously identified genes associated with Snail-mediated squamous cell carcinoma (SCC) invasiveness, in which we observed significant elevation of Cyr61 expression. In this study, SCC cell lines overexpressing Cyr61 exhibited constitutive activation of Rho A and upregulated invasiveness without the disruption of homophilic cell attachment. Humoral Cyr61 enhanced further production of endogenous Cyr61 by SCC cells, which stimulated collective cell migration and the development of an invasive tumor nest. We propose a Cyr61-dependent model for the development of invasive SCC nest, whereby a subset of tumor cells that highly produce Cyr61 may direct other tumor cells to undergo collective cell migration, resulting in a formation of primary SCC mass.

KW - Cyr61

KW - EMT

KW - Snail

KW - Squamous cell carcinoma

KW - Tumor invasion

UR - http://www.scopus.com/inward/record.url?scp=84872485113&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2012.11.023

DO - 10.1016/j.canlet.2012.11.023

M3 - Article

C2 - 23196056

AN - SCOPUS:84872485113

SN - 0304-3835

VL - 329

SP - 243

EP - 252

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous cell carcinoma

Abstract

Keywords

UN SDGs

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