One of the triggers for the disruption of the follicle maturation process along with the oocyte core is the presence of reactive oxygen species (ROS) can affect oxidative stress caused by substances in cigarette smoke. Female passive smokers experience menstrual disorders in the reproductive system, less fetal weight and other reproductive problems. The reality in the community, smoking habits are still difficult to stop, even though health workers and the media have often been socializing about the dangers of cigarette smoke.The aim of study was to explain the effect of cigarette smoke on damage to theca cells in follicles in the ovaries in balb / c mice exposed to cigarette smoke. The subjects used in this study were 20 mice (Mus Musculus) Balbb / c females aged around 8-10 weeks with a bodyweight of 25-30 grams . he results showed the test statistic Mann Whithney smoke increased MDA (Malondeldehide) levels (P= .000), decreased GnRH (Gonadothrophin Relesing Hormone) levels (P= .000) and increased the theca cell apoptosis index (P= .000), and the results of the Independent T-statistic test results Tests showed that exposure to cigarette smoke decreased HSP (Heat Shock Protein) 70 expression (P= .002) and decreased the number of follicles in the ovary (P= .004).

Original languageEnglish
Pages (from-to)774-777
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number2
Publication statusPublished - 29 Jun 2020


  • Apoptosis
  • Cigarette Smoke
  • Follicles
  • GnRH
  • HSP 70
  • MDA
  • Mice


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