Skin penetration of ubiquinone (Co-Q10) in nanoemulsion delivery system using virgin cocunut oil (Vco)

Ubiquinone (co-Q10) is a topical anti-aging with low solubility in water, so its penetration into the skin is also low. To increase its penetration ubiquinone (co-Q10) was loaded in the nanoemulsion delivery system using virgin coconut oil (VCO) as oil phase. Ubiquinone (co-Q10) in nanoemulsion formula consists of; ubiquinone (co-Q10), Tween 80, Span 80, ethanol 96%, VCO and acetate buffer solution pH 4.2 ± 0.5 with concentration; 1%; 18.66%; 1.92%; 3.42%; up to 100%, respectively. The characteristics of ubiquinone (co-Q10) nanoemulsion were observed in terms of droplet morphology by transmission electron microscope (TEM) and droplet size by particle analyzer, the pH and viscosity value. The ubiquinone (co-Q10) penetration test in the nanoemulsion system was compared with the emulsion on the rat skin. Result of this research showed the droplet morphology of ubiquinone (co-Q10) in nanoemulsion was spherical. The droplet size was 93.2 ± 2.78 nm. The pH value was 4.12 ± 0.02, and the viscosity was 8.5 cPas. Penetrasi of ubiquinone (co-Q10) in nanoemulsion was deeper (269 ± 48.12 and 993 ± 36.49 μm) than in emulsion (26.33 ± 6.43 and 110.33 ± 9.124 μm), after 2 and 6 hours sample application.