TY - JOUR
T1 - Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents
AU - Pranoto, Adi
AU - Rejeki, Purwo Sri
AU - Miftahussurur, Muhammad
AU - Setiawan, Hayuris Kinandita
AU - Yosika, Ghana Firsta
AU - Munir, Misbakhul
AU - Maesaroh, Siti
AU - Purwoto, Septyaningrum Putri
AU - Waritsu, Cakra
AU - Yamaoka, Yoshio
N1 - Funding Information:
Research funding: This study is supported by the Directorate of Research and Community Services, Deputy for Strengthening Research and Development of the Ministry of Research and Technology/National Research and Innovation Agency, Indonesia, under Grand Number: 4/E1/KP.PTNBH/2021 and 292/UN3.15/PT/2021.
Publisher Copyright:
© 2023 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Objectives: Regular treadmill exercise may result in changes in pro-inflammatory cytokines and oxidative stress. However, the way acute treadmill exercise mechanisms affect the changes in pro-inflammatory cytokines and oxidative stress in obese has not been comprehensively exposed. This study aimed to analyze the pro-inflammatory cytokines and oxidative stress between 30 min before treadmill exercise and 24 h after treadmill exercise in obese adolescents. Methods: A total of 20 obese females aged 19-24 years were recruited from female students and given one session of treadmill exercise with an intensity of 60-70% HRmax. Thiobarbituric acid reactive substance (TBARS) was used to analyze serum levels of MDA, while enzyme-linked immunosorbent assay (ELISA) was used to analyze serum levels of TNF-α and IL-6. Moreover, the independent samples t-test with a significance level of 5% was employed to have the statistical analysis. Results: The results on 24 h after treadmill exercise and delta (Δ) between CTRL and TREG showed a significant difference (p<0.001). Conclusions: This study found a decrease in pro-inflammatory cytokines and oxidative stress 24 h after treadmill exercise in obese adolescents. Therefore, treadmill exercise can be a promising strategy for preventing adolescents from obesity as well as preventing disease risks associated with oxidative stress and chronic inflammation.
AB - Objectives: Regular treadmill exercise may result in changes in pro-inflammatory cytokines and oxidative stress. However, the way acute treadmill exercise mechanisms affect the changes in pro-inflammatory cytokines and oxidative stress in obese has not been comprehensively exposed. This study aimed to analyze the pro-inflammatory cytokines and oxidative stress between 30 min before treadmill exercise and 24 h after treadmill exercise in obese adolescents. Methods: A total of 20 obese females aged 19-24 years were recruited from female students and given one session of treadmill exercise with an intensity of 60-70% HRmax. Thiobarbituric acid reactive substance (TBARS) was used to analyze serum levels of MDA, while enzyme-linked immunosorbent assay (ELISA) was used to analyze serum levels of TNF-α and IL-6. Moreover, the independent samples t-test with a significance level of 5% was employed to have the statistical analysis. Results: The results on 24 h after treadmill exercise and delta (Δ) between CTRL and TREG showed a significant difference (p<0.001). Conclusions: This study found a decrease in pro-inflammatory cytokines and oxidative stress 24 h after treadmill exercise in obese adolescents. Therefore, treadmill exercise can be a promising strategy for preventing adolescents from obesity as well as preventing disease risks associated with oxidative stress and chronic inflammation.
KW - IL-6
KW - MDA
KW - TNF-α
KW - obesity
KW - treadmill exercise
UR - http://www.scopus.com/inward/record.url?scp=85148673275&partnerID=8YFLogxK
U2 - 10.1515/jbcpp-2022-0196
DO - 10.1515/jbcpp-2022-0196
M3 - Article
C2 - 36804995
AN - SCOPUS:85148673275
SN - 0792-6855
VL - 34
SP - 235
EP - 242
JO - Journal of Basic and Clinical Physiology and Pharmacology
JF - Journal of Basic and Clinical Physiology and Pharmacology
IS - 2
ER -