TY - GEN
T1 - Serum progesteron induced blocking factor (PIBF) level in Mus Musculus as endothelial dysfunction model and given mild regular exercise
AU - Noor, Meitria Syahadatina
AU - Santoso, Budi
AU - Triawanti,
AU - Widjiati,
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/6/4
Y1 - 2019/6/4
N2 - Maternal mortality rate (MMR) in Indonesia is still high. One of the causes of MMR in Indonesia 2010- 2013 was hypertension in pregnant (preeclampsia). Effect of preeclampsia was a complication for mother and baby. One of the mechanisms of preeclampsia was immune response, there were natural killer cells which induced inflammation. PIBF was a pregnancy protector factor by inhibiting NK lymphocytes and increasing anti- inflammation. Mild regular exercise induced IL6 to make IL10 higher. This research's objective was to analyze serum PIBF level because of mild regular exercise in Mus musculus as endothelial dysfunction model induced preeclampsia. This research was true experimental using post test only with control group design. This research consisted of 4 groups: K1 (normal pregnant mice), K2 (endothelial dysfunction model), K3 (endothelial dysfunction model with mild regular exercise since early pregnant), and K4 (endothelial dysfunction model with mild regular exercise since 1 week before pregnant). The exercise used a treadmill without angle for 18 minutes once in 2 days for 2 weeks. The results were serum PIBF level in K1 was 11,982 ng/ml, in K2 was 11,609 ng/ml, in K3 was 7,256 ng/ml, and in K4 was 19,731 ng/ml. Data distribution was not in normal, so data were analyzed by Kruskal Wallis Test with α=0,05. The result was no significant differences of serum PIBF level (p=0,076). The conclusion was mild regular exercise had not increased serum PIBF level yet significantly.
AB - Maternal mortality rate (MMR) in Indonesia is still high. One of the causes of MMR in Indonesia 2010- 2013 was hypertension in pregnant (preeclampsia). Effect of preeclampsia was a complication for mother and baby. One of the mechanisms of preeclampsia was immune response, there were natural killer cells which induced inflammation. PIBF was a pregnancy protector factor by inhibiting NK lymphocytes and increasing anti- inflammation. Mild regular exercise induced IL6 to make IL10 higher. This research's objective was to analyze serum PIBF level because of mild regular exercise in Mus musculus as endothelial dysfunction model induced preeclampsia. This research was true experimental using post test only with control group design. This research consisted of 4 groups: K1 (normal pregnant mice), K2 (endothelial dysfunction model), K3 (endothelial dysfunction model with mild regular exercise since early pregnant), and K4 (endothelial dysfunction model with mild regular exercise since 1 week before pregnant). The exercise used a treadmill without angle for 18 minutes once in 2 days for 2 weeks. The results were serum PIBF level in K1 was 11,982 ng/ml, in K2 was 11,609 ng/ml, in K3 was 7,256 ng/ml, and in K4 was 19,731 ng/ml. Data distribution was not in normal, so data were analyzed by Kruskal Wallis Test with α=0,05. The result was no significant differences of serum PIBF level (p=0,076). The conclusion was mild regular exercise had not increased serum PIBF level yet significantly.
KW - endhotelial dysfunction model
KW - mild regular exercise
KW - serum PIBF
UR - http://www.scopus.com/inward/record.url?scp=85066994677&partnerID=8YFLogxK
U2 - 10.1063/1.5109997
DO - 10.1063/1.5109997
M3 - Conference contribution
AN - SCOPUS:85066994677
T3 - AIP Conference Proceedings
BT - International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research
A2 - Budianto, Windy Yuliana
A2 - Sujuti, Hidayat
A2 - Khotimah, Husnul
PB - American Institute of Physics Inc.
T2 - 3rd Annual Scientific Meeting of Indonesian Consortium for Biomedical Sciences, ASMICBS 2018
Y2 - 21 November 2018 through 23 November 2018
ER -
