Serum krebs von den lungen-6 for predicting the severity of COVID-19 lung injury: A systematic review and meta-analysis

Andro Pramana Witarto, Bendix Samarta Witarto, Achmad Januar Er Putra, Shidi Laras Pramudito, Alfian Nur Rosyid

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Introduction: Lung injury is common in COVID-19 patients. The severity of lung injury appears to be reflected in serum KL-6, a glycoprotein expressed on type II alveolar epithelium. This study aims to assess the role of serum KL-6 in reflecting the severity of lung injury in COVID-19 patients. Methods: A systematic search was conducted in Scopus, PubMed, Wiley Online Library, and ProQuest. Articles were screened based on several eligibility criteria and assessed for study quality using NOS. Results: This systematic review included four studies involving a total of 151 adult COVID-19 patients. Pooled analysis revealed that serum KL-6 was significantly higher in severe patients (SMD = 1.16; 95% CI = 0.69–1.63) with moderately high pooled sensitivity (79%; 95% CI = 61–91%) and specificity (86%; 95% CI = 72–95%). Conclusion: High serum KL-6 may depict more severe lung injury in COVID-19 patients with moderately high sensitivity and specificity.

Original languageEnglish
Pages (from-to)381-389
Number of pages9
JournalIranian Biomedical Journal
Volume25
Issue number6
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Biomarker
  • COVID-19
  • Infectious disease
  • Krebs von den Lungen-6
  • Lung injury

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