Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis b patients

Titong Sugihartono; Ivan Pratama Alimsardjono; Ummi Maimunah; Iswan Abbas Nusi; Herrry Purbayu; Ulfa Kholili; Budi Widodo; Muhammad Miftahussurur; Husin Thamrin; Amie Vidyani; Poernomo Boedi Setiawan

Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis b patients

Titong Sugihartono, Ivan Pratama Alimsardjono, Ummi Maimunah, Iswan Abbas Nusi, Herrry Purbayu, Ulfa Kholili, Budi Widodo, Muhammad Miftahussurur, Husin Thamrin, Amie Vidyani, Poernomo Boedi Setiawan

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Serum hyaluronic acid has an important role in the pathogenesis of liver fibrosis and is one of the most studied extracellular liver matrices. The purpose of this study was to examine the relationship between serum hyaluronic acid level and liver stiffness in hepatitis B chronic patients. Methods: This was an observational cross-sectional analytic study consisting of 43 samples of chronic hepatitis B patients. Serum hyaluronic acid was measured by the ELISA method. Liver stiffness describing fibrosis was examined using Fibro scan. Results: Among forty-three subject was predominantly by females (65.1%). The average age of the study subjects was 44.023 years old. The median serum hyaluronic acid level of the study subjects was 40.318 ng/mL. The median liver stiffness in the study subjects was 5.8 kPa. There was a significant positive correlation between serum hyaluronic acid levels and liver stiffness in the study subjects with a moderate strength of r = 0.448 (P = 0.003). Conclusion: Serum hyaluronic acid levels associated with liver stiffness.

Original language	English
Pages (from-to)	1745-1749
Number of pages	5
Journal	EurAsian Journal of BioSciences
Volume	14
Issue number	1
Publication status	Published - 1 Jan 2020

Keywords

Hepatitis B virus infection
Hyaluronic acid
Liver stiffness

Cite this

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title = "Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis b patients",

abstract = "Background: Serum hyaluronic acid has an important role in the pathogenesis of liver fibrosis and is one of the most studied extracellular liver matrices. The purpose of this study was to examine the relationship between serum hyaluronic acid level and liver stiffness in hepatitis B chronic patients. Methods: This was an observational cross-sectional analytic study consisting of 43 samples of chronic hepatitis B patients. Serum hyaluronic acid was measured by the ELISA method. Liver stiffness describing fibrosis was examined using Fibro scan. Results: Among forty-three subject was predominantly by females (65.1%). The average age of the study subjects was 44.023 years old. The median serum hyaluronic acid level of the study subjects was 40.318 ng/mL. The median liver stiffness in the study subjects was 5.8 kPa. There was a significant positive correlation between serum hyaluronic acid levels and liver stiffness in the study subjects with a moderate strength of r = 0.448 (P = 0.003). Conclusion: Serum hyaluronic acid levels associated with liver stiffness.",

keywords = "Hepatitis B virus infection, Hyaluronic acid, Liver stiffness",

author = "Titong Sugihartono and Alimsardjono, {Ivan Pratama} and Ummi Maimunah and Nusi, {Iswan Abbas} and Herrry Purbayu and Ulfa Kholili and Budi Widodo and Muhammad Miftahussurur and Husin Thamrin and Amie Vidyani and Setiawan, {Poernomo Boedi}",

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language = "English",

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pages = "1745--1749",

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T1 - Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis b patients

AU - Sugihartono, Titong

AU - Alimsardjono, Ivan Pratama

AU - Maimunah, Ummi

AU - Nusi, Iswan Abbas

AU - Purbayu, Herrry

AU - Kholili, Ulfa

AU - Widodo, Budi

AU - Miftahussurur, Muhammad

AU - Thamrin, Husin

AU - Vidyani, Amie

AU - Setiawan, Poernomo Boedi

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background: Serum hyaluronic acid has an important role in the pathogenesis of liver fibrosis and is one of the most studied extracellular liver matrices. The purpose of this study was to examine the relationship between serum hyaluronic acid level and liver stiffness in hepatitis B chronic patients. Methods: This was an observational cross-sectional analytic study consisting of 43 samples of chronic hepatitis B patients. Serum hyaluronic acid was measured by the ELISA method. Liver stiffness describing fibrosis was examined using Fibro scan. Results: Among forty-three subject was predominantly by females (65.1%). The average age of the study subjects was 44.023 years old. The median serum hyaluronic acid level of the study subjects was 40.318 ng/mL. The median liver stiffness in the study subjects was 5.8 kPa. There was a significant positive correlation between serum hyaluronic acid levels and liver stiffness in the study subjects with a moderate strength of r = 0.448 (P = 0.003). Conclusion: Serum hyaluronic acid levels associated with liver stiffness.

AB - Background: Serum hyaluronic acid has an important role in the pathogenesis of liver fibrosis and is one of the most studied extracellular liver matrices. The purpose of this study was to examine the relationship between serum hyaluronic acid level and liver stiffness in hepatitis B chronic patients. Methods: This was an observational cross-sectional analytic study consisting of 43 samples of chronic hepatitis B patients. Serum hyaluronic acid was measured by the ELISA method. Liver stiffness describing fibrosis was examined using Fibro scan. Results: Among forty-three subject was predominantly by females (65.1%). The average age of the study subjects was 44.023 years old. The median serum hyaluronic acid level of the study subjects was 40.318 ng/mL. The median liver stiffness in the study subjects was 5.8 kPa. There was a significant positive correlation between serum hyaluronic acid levels and liver stiffness in the study subjects with a moderate strength of r = 0.448 (P = 0.003). Conclusion: Serum hyaluronic acid levels associated with liver stiffness.

KW - Hepatitis B virus infection

KW - Hyaluronic acid

KW - Liver stiffness

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VL - 14

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EP - 1749

JO - EurAsian Journal of BioSciences

JF - EurAsian Journal of BioSciences

IS - 1

ER -

Serum hyaluronic acid and its association with liver stiffness in chronic hepatitis b patients

Abstract

Keywords

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