Serum calcidiol (25(oh)d) and its association with disease activity in psoriatic arthritis patients

Background: One of the environmental risk factors that has been considered to play a role in psoriatic arthritis (PsA) pathogenesis is vitamin D. Hypovitaminosis D is often found among PsA patients. This study aimed to evaluate the correlation between serum 25(OH)D levels and disease activity of PsA using DAPSA score. Method: Serum 25(OH)D was examined using the CMIA method, and PsA disease activity was measured using a DAPSA score. Result: Median age was 49.5 (20-60) years with predominantly female subjects (73%). Mean serum 25(OH)D was 17.06±6.51 ng/mL; deficiency was found in 23 patients (67.6%), insufficiency was found in 11 patients (32.4%), and no patient was with normal 25(OH)D level. Mean DAPSA score was 24.25±3.99; 29 patients (85.3%) had moderate disease activity, 5 patients (14.7%) had high disease activity, and no subjects with remission and mild disease activity were found. A significant correlation was found between 25(OH)D levels and DAPSA score (r =-0.56, p = 0.001). Conclusion: The 25(OH)D level was associated with PsA disease activity using DAPSA score.