Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia

Takako Utsumi; Yoshihiko Yano; Maria Inge Lusida; Mochamad Amin; Hak Hotta; Yoshitake Hayashi

doi:10.4269/ajtmh.2010.09-0589

Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia

Takako Utsumi, Yoshihiko Yano, Maria Inge Lusida, Mochamad Amin, Soetjipto, Hak Hotta, Yoshitake Hayashi

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	American Journal of Tropical Medicine and Hygiene
Volume	83
Issue number	1
DOIs	https://doi.org/10.4269/ajtmh.2010.09-0589
Publication status	Published - Jul 2010

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abstract = "Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.",

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T1 - Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia

AU - Utsumi, Takako

AU - Yano, Yoshihiko

AU - Lusida, Maria Inge

AU - Amin, Mochamad

AU - Soetjipto,

AU - Hotta, Hak

AU - Hayashi, Yoshitake

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AB - Universal childhood hepatitis B vaccination was introduced in Indonesia in 1997; by 2008, coverage was estimated to be 78%. This study aimed to investigate the serologic status and virologic characteristics of hepatitis B virus (HBV) among the children in East Java. A total of 229 healthy children born during 1994-1999 were enrolled in this study. Overall, 3.1% were positive for hepatitis B surface antigen (HBsAg) and 23.6% were positive for antibody to HBsAg (anti-HBs). HBV DNA was detected in 5 of 222 HBsAg-negative carriers, which were suggested to be cases of occult HBV infection. A single amino substitution (T126I) in the S region was frequently found. HBV infection remains endemic, and the prevalence of anti-HBs remains insufficient among children in East Java, Indonesia.

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Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia

Abstract

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