Plants are the key source for the production of novel therapeutic products for new medicines. The biological properties of the plant species used world wide are mainly accountable for their secondary metabolites obtained from plants. The goal of this analysis is to summarize the chemical composition and biological effects of the genus Sida (Malvaceae) to identify potential research opportunities. This analysis draws on the literature review of scientific journals, and books from libraries, and electronic sources like ScienceDirect, Springer, PubMed, ResearchGate, Google Scholar, and the Website. Some groups of secondary metabolite compounds isolated from the genus Sida include alkaloids, flavonoids, coumarin, and others. Pharmacological experiments found that there are a wide variety of biological activities in extracts and compounds isolated from the genus Sida comprising antimalarial, antiplasmodial, antimicrobial, analgesic, antibacterial, antioxidant, vasorelaxant, wound healing, antifungal activities, the inhibition of quinone reductase, and mouse mammary organ culture.