TY - JOUR
T1 - Screening for potential antidiabetes and antioxidant activities of selected plants from East Kalimantan, Indonesia
AU - Ramadhan, Rico
AU - Kristanti, Alfinda Novi
AU - Amirta, Rudianto
AU - Kusuma, Irawan Wijaya
AU - Phuwapraisirisan, Preecha
AU - Haqiqi, Muhammad Taufiq
AU - Saparwadi,
N1 - Publisher Copyright:
© 2019, Society for Indonesian Biodiversity. All rights reserved.
PY - 2019/7
Y1 - 2019/7
N2 - Ten selected plants in this study have been used traditionally in West Kutai, East Kalimantan as medicinal plants. This study aimed to screen and evaluate the in vitro antidiabetic and antioxidant activity of methanol extracts of selected plants from East Kalimantan. The antidiabetic activity was carried out by α-glucosidase inhibitory activity with maltose and sucrose as substrates while antioxidant activity was determined by free radicals scavenging activity against DPPH, ABTS and Nitric Oxide (NO). The results showed that Garcinia riedeliana extract had strong inhibitory activity with an IC50 value of 0.04 mg/mL followed by Shorea laevis, Pternandra azurea and Bridelia tomentosa with IC50 values of 0.12; 0.15 and 0.16 mg/mL in maltose respectively, while quercetin as positive control had an IC50 value of 0.08 mg/mL. G.riedeliana extract also showed good α-glucosidase inhibitory activity with an IC50 value of 0.23 mg/mL in sucrose as substrate. The results on antioxidant activity showed that all extracts have IC50 value against free radicals DPPH, ABTS, and nitric oxide. The most active extract as α-glucosidase inhibitory activity and antioxidant activity was G. riedeliana extract. These findings provide the scientific evidence that one species of medicinal plants from East Kalimantan might be potential as an antioxidant and α-glucosidase inhibitor.
AB - Ten selected plants in this study have been used traditionally in West Kutai, East Kalimantan as medicinal plants. This study aimed to screen and evaluate the in vitro antidiabetic and antioxidant activity of methanol extracts of selected plants from East Kalimantan. The antidiabetic activity was carried out by α-glucosidase inhibitory activity with maltose and sucrose as substrates while antioxidant activity was determined by free radicals scavenging activity against DPPH, ABTS and Nitric Oxide (NO). The results showed that Garcinia riedeliana extract had strong inhibitory activity with an IC50 value of 0.04 mg/mL followed by Shorea laevis, Pternandra azurea and Bridelia tomentosa with IC50 values of 0.12; 0.15 and 0.16 mg/mL in maltose respectively, while quercetin as positive control had an IC50 value of 0.08 mg/mL. G.riedeliana extract also showed good α-glucosidase inhibitory activity with an IC50 value of 0.23 mg/mL in sucrose as substrate. The results on antioxidant activity showed that all extracts have IC50 value against free radicals DPPH, ABTS, and nitric oxide. The most active extract as α-glucosidase inhibitory activity and antioxidant activity was G. riedeliana extract. These findings provide the scientific evidence that one species of medicinal plants from East Kalimantan might be potential as an antioxidant and α-glucosidase inhibitor.
KW - Anti-diabetic
KW - Antioxidant
KW - East kalimantan
KW - Free radical scavenging
KW - α-glucosidase
UR - http://www.scopus.com/inward/record.url?scp=85070760631&partnerID=8YFLogxK
U2 - 10.13057/biodiv/d200705
DO - 10.13057/biodiv/d200705
M3 - Article
AN - SCOPUS:85070760631
SN - 1412-033X
VL - 20
SP - 1820
EP - 1826
JO - Biodiversitas
JF - Biodiversitas
IS - 7
ER -