Sanjecumins A and B: New limonoids from Sandoricum koetjape

Yuta Nagakura; Alfarius Eko Nugroho; Yusuke Hirasawa; Takahiro Hosoya; Abdul Rahman; Idha Kusumawati; Noor Cholies Zaini; Hiroshi Morita

doi:10.1007/s11418-012-0677-4

Sanjecumins A and B: New limonoids from Sandoricum koetjape

Yuta Nagakura, Alfarius Eko Nugroho, Yusuke Hirasawa, Takahiro Hosoya, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide.

Original language	English
Pages (from-to)	381-385
Number of pages	5
Journal	Journal of Natural Medicines
Volume	67
Issue number	2
DOIs	https://doi.org/10.1007/s11418-012-0677-4
Publication status	Published - Apr 2013

Keywords

Sandoricum koetjape
Sanjecumins A and B
iNOS inhibition activity

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10.1007/s11418-012-0677-4

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title = "Sanjecumins A and B: New limonoids from Sandoricum koetjape",

abstract = "Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide.",

keywords = "Sandoricum koetjape, Sanjecumins A and B, iNOS inhibition activity",

author = "Yuta Nagakura and Nugroho, {Alfarius Eko} and Yusuke Hirasawa and Takahiro Hosoya and Abdul Rahman and Idha Kusumawati and Zaini, {Noor Cholies} and Hiroshi Morita",

note = "Funding Information: Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant from the Open Research Center Project of Hoshi University.",

year = "2013",

month = apr,

doi = "10.1007/s11418-012-0677-4",

language = "English",

volume = "67",

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T1 - Sanjecumins A and B

T2 - New limonoids from Sandoricum koetjape

AU - Nagakura, Yuta

AU - Nugroho, Alfarius Eko

AU - Hirasawa, Yusuke

AU - Hosoya, Takahiro

AU - Rahman, Abdul

AU - Kusumawati, Idha

AU - Zaini, Noor Cholies

AU - Morita, Hiroshi

N1 - Funding Information: Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and a grant from the Open Research Center Project of Hoshi University.

PY - 2013/4

Y1 - 2013/4

N2 - Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide.

AB - Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide.

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KW - iNOS inhibition activity

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Sanjecumins A and B: New limonoids from Sandoricum koetjape

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Keywords

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