In osteoarthritis post-menopause, decreasing estrogen influenced formation of chondrocyte hypertrophy. This study would explain role of RUNX2 and SOX9 to chondrocyte hypertrophy formation in decreasing estrogen condition. Fifty four rats were divided into six groups. Level of 17 β estradiol and TGF-β were examined by ELISA. SOX9 and RUNX2 used immunohistochemistry. Histopathology for chondrocyte hypertrophy. Level of 17 β estradiol and SOX9 on treatment group decreased significantly, TGF-β and RUNX2 increased significantly. Chondrocyte hypertrophy increased significantly in treatment group. The decreasing of 17 β estradiol level caused increasing hypertrophy Chondrocyte through increasing level of TGF-β and RUNX2.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalIndian Veterinary Journal
Issue number10
Publication statusPublished - 2019


  • Chondrocyte hypertrophy
  • Estrogen
  • RUNX2
  • TGF-β


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