TY - JOUR
T1 - Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs
AU - Haque, Nazmul
AU - Fareez, Ismail M.
AU - Fong, Liew Fong
AU - Mandal, Chanchal
AU - Kasim, Noor Hayaty Abu
AU - Kacharaju, Kranthi Raja
AU - Soesilawati, Pratiwi
N1 - Funding Information:
Supported by MAHSA University Grant, No. RP158-05/19.
Publisher Copyright:
© The Author(s) 2020.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - In recent years, several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted cells. These findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor cells. Interestingly, this notion has also led scientists to question the role of proteins in the secretome produced by cells, tissues or organisms under certain conditions or at a particular time of regenerative therapy. Further studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected organs. This could also facilitate the migration of immune, progenitor and stem cells within the body to the site of inflammation. Of these different paracrine factors present within the secretome, researchers have given proper consideration to stromal cell-derived factor-1 (SDF1) that plays a vital role in tissue-specific migration of the cells needed for regeneration. Recently researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue regeneration. Hence in this study, we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.
AB - In recent years, several studies have reported positive outcomes of cell-based therapies despite insufficient engraftment of transplanted cells. These findings have created a huge interest in the regenerative potential of paracrine factors released from transplanted stem or progenitor cells. Interestingly, this notion has also led scientists to question the role of proteins in the secretome produced by cells, tissues or organisms under certain conditions or at a particular time of regenerative therapy. Further studies have revealed that the secretomes derived from different cell types contain paracrine factors that could help to prevent apoptosis and induce proliferation of cells residing within the tissues of affected organs. This could also facilitate the migration of immune, progenitor and stem cells within the body to the site of inflammation. Of these different paracrine factors present within the secretome, researchers have given proper consideration to stromal cell-derived factor-1 (SDF1) that plays a vital role in tissue-specific migration of the cells needed for regeneration. Recently researchers recognized that SDF1 could facilitate site-specific migration of cells by regulating SDF1-CXCR4 and/or HMGB1-SDF1-CXCR4 pathways which is vital for tissue regeneration. Hence in this study, we have attempted to describe the role of different types of cells within the body in facilitating regeneration while emphasizing the HMGB1-SDF1-CXCR4 pathway that orchestrates the migration of cells to the site where regeneration is needed.
KW - C-X-C motif chemokine 12
KW - Mesenchymal stem cells
KW - Monocytes
KW - Neutrophils
KW - Peripheral blood mononuclear cells
KW - Receptor for advanced glycation end products
UR - http://www.scopus.com/inward/record.url?scp=85091419504&partnerID=8YFLogxK
U2 - 10.4252/wjsc.v12.i9.938
DO - 10.4252/wjsc.v12.i9.938
M3 - Article
AN - SCOPUS:85091419504
SN - 1948-0210
VL - 12
SP - 938
EP - 951
JO - World Journal of Stem Cells
JF - World Journal of Stem Cells
IS - 9
ER -
