Psoriasis is a chronic and recurring inflammatory condition that can occur locally in the skin and systemically. Psoriasis causes significant morbidity and reduces quality of life of its patients. Microbiota and its metabolites are known to play a significant role in both innate and adaptive immune regulation. Disruption of microbial homeostasis known as dysbiosis, can lead to alterations in immunological regulation and disruption of the gastrointestinal barrier. The gut microbiota composes the largest microbiome in the human body. Changes in the diversity of the gut microbiotas and their metabolites are reported in psoriasis patients. Dysbiosis is thought to contribute and intensify the inflammatory process in psoriasis. Probiotics are widely utilized and well-known for its safety profile. Probiotics are currently being widely studied as a therapy for skin disorders, including psoriasis. Probiotics may increase the variety of commensal microbiota, decrease pathobionts, and restore the damaged gastrointestinal epithelium. Probiotic supplementation is expected to ameliorate the dysbiosis that occurs in psoriasis and become a promising adjuvant therapy in psoriasis.
|Number of pages
|Journal of Pakistan Association of Dermatologists
|Published - Jul 2023