Role of estrogens in maintenance therapy of patients with pelvic organ prolapse. A systematic review

Eighty Mardiyan Kurniawati, Nur Anisah Rahmawati, Gatut Hardianto, Hari Paraton, Tri Hastono Setyo Hadi, Anis Widyasari

Research output: Contribution to journalReview articlepeer-review

Abstract

Pelvic floor dysfunction is one of the causes of female morbidity, which reduces the quality of life of patients. To improve the results of treatment using pessaries or preparation for surgical treatment, supportive therapy is necessary, for example, with estrogens, which are preferred and most effective in the treatment of certain urogenital diseases. A systematic review of clinical recommendations (Preferred Reporting Items for Systematic Review and Meta-Analyses — PRISMA) devoted to the study of the role of estrogens as an accompanying therapy in the treatment of patients with genital prolapse was conducted. English-language publications were studied in five databases (Google Scholar, ScienceDirect, PubMed, ProQuest and Scopus) using several keywords. The cri-teria for inclusion of selected articles were cohort and randomized controlled trials published in 2012-2022. Results. The study included 495 postmenopausal women with genital prolapse who used vaginal pessary and 192 patients who planned surgical treatment for genital prolapse. The use of estrogens in preoperative preparation and in the use of pessaries showed different results, but demonstrated the effectiveness of their use. Not all studies have examined the side effects of estrogen use. No side effects were identified in two publications, and one publication described a side effect — a burning sensation and/or pain in the vagina. Conclusion. Further research is needed to confirm the safe dosage of the drug and the duration of treatment in order to obtain better outcomes.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalRussian Bulletin of Obstetrician-Gynecologist
Volume24
Issue number5
DOIs
Publication statusPublished - 2024

Keywords

  • estrogens
  • pessary
  • surgical treatment
  • treatment of patients with pelvic organ prolapse

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