Role of Alkaloid on Platelet Aggregation and Serotonin in Migraine

Olivia Mahardani Adam, Widjiati Widjiati

Research output: Contribution to journalArticlepeer-review


Migraine is a sterile neurogenic inflammation of the trigeminal nerve which releases vasoactive neuropeptides and activates platelets to release vasoactive substances such as serotonin (5-HT). Platelet hyperaggregation occurs in the pathogenesis of migraine caused by one of the stimulatory factors 5-HT. Platelet aggregation is increased and 5-HT levels are elevated in the blood and brain in the early stages of migraine. Alkaloid β-carbolin alkaloids can increase monoamines in brain regions through inhibition of monoamine oxidase (MAO) and inhibition of 5-HT reuptake. Alkaloids in the ethanolic extract of SCE function as analgesics and anti-inflammatory which can reduce pain and improve blood circulation. Sargassum cristaefolium extract (SCE) was measured for its bioactive substance content. The extract was administered to an animal model of intraperitoneal nitroglycerin-induced migraine and examined for platelet levels, platelet aggregation and 5-HT. The results of statistical tests showed an increase in platelets (p<0.05), an increase in platelet aggregation (p<0.05) and a decrease in 5-HT (p<0.05). The relationship between alkaloids and platelets; platelets and platelet aggregation; platelet aggregation and 5-HT and 5-HT levels and migraine incidence (p<0.05). The alkaloids found in SCE can lower platelet count, decrease platelet aggregation and increase 5-HT levels in migraines.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalPharmacognosy Journal
Issue number3
Publication statusPublished - May 2022


  • Alkaloid
  • Migraine
  • Platelet
  • Platelet aggregation
  • Serotonin


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