TY - JOUR
T1 - Risk Factors Associated with Nasopharyngeal Cancer Incidences in Indonesia
T2 - A Systematic Review and Meta-Analysis
AU - Romdhoni, Achmad Chusnu
AU - Rejeki, Purwo Sri
AU - Guo, How Ran
AU - Milla, Clonia
AU - Melbiarta, Rezy Ramawan
AU - Visuddho, Visuddho
AU - Nugraha, David
N1 - Publisher Copyright:
© This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License
PY - 2023
Y1 - 2023
N2 - Objective: To determine the risk factors associated the incidence of NPC, particularly in Indonesia. Methods: This systematic review and meta-analysis was conducted according to PRISMA statement. Database including PubMed, Scopus, Science Direct, Web of Science, and GARUDA were retrieved. Newcastle-Ottawa scale was used to assess the quality of published study and analyse the risk of bias of included study. Random-effect model and reported pooled Odds Ratio (OR) with 95%CI was carried out in our meta-analysis. Results: A pooled of 7 studies were included in our study which included 764 participants. We found that female gender was not associated with the incidences of NPC (OR 1.45, 95% CI: 0.61-3.45, p=0.40), and smoking was highly increased the incidence of NPC (OR 4.39 95% CI (0.79-24.40), but not statistically significant (p=0.09). Furthermore, salted fish consumption and some HLA alleles were associated with increased risk. Conclusion: The incidence of NPC is not associated with female gender nor smoking habits. However, the risk of NPC is higher for those who consume salted fish and have some susceptible HLA alleles.
AB - Objective: To determine the risk factors associated the incidence of NPC, particularly in Indonesia. Methods: This systematic review and meta-analysis was conducted according to PRISMA statement. Database including PubMed, Scopus, Science Direct, Web of Science, and GARUDA were retrieved. Newcastle-Ottawa scale was used to assess the quality of published study and analyse the risk of bias of included study. Random-effect model and reported pooled Odds Ratio (OR) with 95%CI was carried out in our meta-analysis. Results: A pooled of 7 studies were included in our study which included 764 participants. We found that female gender was not associated with the incidences of NPC (OR 1.45, 95% CI: 0.61-3.45, p=0.40), and smoking was highly increased the incidence of NPC (OR 4.39 95% CI (0.79-24.40), but not statistically significant (p=0.09). Furthermore, salted fish consumption and some HLA alleles were associated with increased risk. Conclusion: The incidence of NPC is not associated with female gender nor smoking habits. However, the risk of NPC is higher for those who consume salted fish and have some susceptible HLA alleles.
KW - Indonesia
KW - Nasopharyngeal cancer
KW - gender
KW - salted fish
KW - smoking
UR - http://www.scopus.com/inward/record.url?scp=85158122548&partnerID=8YFLogxK
U2 - 10.31557/APJCP.2023.24.4.1105
DO - 10.31557/APJCP.2023.24.4.1105
M3 - Review article
AN - SCOPUS:85158122548
SN - 1513-7368
VL - 24
SP - 1105
EP - 1111
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 4
ER -