Review: Application of Polysaccharide Polymer Combination in Microsphere Delivery System for Anti-Tuberculosis

Tuberculosis is still a health problem both in Indonesia and in the world and is one of the leading causes of death. Unfortunately, the first-line OAT therapy that is currently recommended in Indonesia has some limitations, namely requiring a long duration of treatment and starting to find cases of resistance in its use. Drug Delivery System is one of the solutions to this problem, as a formulation or system that is able to mediate the delivery of therapeutic substances in the body to increase therapeutic effects, reduce drug side effects, increase bioavailability and improve patient compliance. Purpose: Therefore, in this review we will review the polysaccharide polymers used as microsphere delivery systems as anti-tubeculosis treatment. The review of this article was made using the library research method obtained through Google Scholar, PubMed, Scopus, NCBI, Elsevier with the keywords "Drug Delivery Pulmonary", "Polysaccharide Polymer for Pulmonary", "Chitosan Polymer", "Sodium Alginate Polymer", "Carrageenan Polymer", "Pectin Polymer", "Antibiotics Chitosan-Na.Alginate Pulmonary", "Antibiotics Chitosan-Pectin Antibiotics", "Antibiotics Na.Alginate - Pulmonary Carrageenan", "Antibiotics for Tuberculosis", "Drug Delivery for Anti Tuberculosis". The use of polymer combination is an option in order to complement the shortcomings of each of the other polymers, then it can produce controlled-release drugs, which have the advantage of reducing the frequency of dosing, reducing drug side effects, increasing the level of patient compliance which can certainly be a solution for the development of anti-tuberculosis drugs.