Response of Pro-Inflammatory Cytokines After A Single Bout of Moderate-Intensity Endurance Exercise in Obese

Reducing the complications of obesity by controlling the balance of inflammation and losing weight with physical exercise can be used as a strategy to overcome obesity problems. This study aims to prove the effect of moderate-intensity endurance exercise on the acute response of proinflammatory cytokines in obese women. A total of 22 obese women aged 20-24 years, with body mass index 27-33 kg/m2, and body fat percentage ≥30%, were selected to be respondents and given moderate-intensity endurance exercise intervention (60-70% HRmax) for 40 minutes. ELISA Kit was applied to evaluate TNF-α levels in all samples. The data analysis technique uses an independent sample t-test with a significance level of 5%. The results show the average TNF-α levels between the control (CON) vs endurance exercise group (END) in pre-exercise (5.47±2.19 vs 5.39±1.45 pg/mL, p=0.932), post-exercise (5.76±2.08 vs 3.68±2.10 pg/mL, p=0.039), delta (value of pre-exercise - post-exercise) (0.29±2.27 vs -1.72±1.04 pg/mL, p=0.020). This study consistently proves that one session of moderate-intensity endurance exercise for 40 minutes reduces TNF-α levels in obese women.