Relationship between high sensitivity tnf-α with clinical outcome during admission in acute ischemic stroke

Background: Tumor necrosis factor alpha (TNF-α), together with other pro-inflammatory cytokines such as Interleukin-1b (IL-1b), IL-6 and IL-8, play a role in the ischemic injury of the central nervous system. TNF-α has adverse effects on ischemic brain tissue. The mechanism generated is a multicomplex process. In other studies, an increase in TNF-α can actually have neuroprotective effects. This study aims to determine the relation between the levels of the High Sensitivity TNF-α with clinical outcome in acute ischemic stroke. Method: Thirty patients with acute ischemic stroke patients who admitted in Dr. Soetomo hospital Surabaya during the period December 2011 to February 2012. 2 cc of vein blood for examination High sensitivity TNF-α was drawn during admission from acute ischemic stroke. Clinical outcome in acute stroke was measured by NIHSS score. Results: From 30 research samples, the mean age of patients was 59.53 ± 11.51 years. The mean High Sensitivity TNF-α level in the study subjects was 2 ± 0.99 pg / ml. NIHSS examination showed the median value of the NIHSS was 5 with a range of 2-19. There is a correlation but not statistically significant with the strength is very weak between High Sensitivity TNF-α with the NIHSS in patients with acute thrombotic stroke (r = 0.100 and p = 0.600). Conclusion: There is relationship between serum levels of High sensitivity TNF-α with clinical outcome in acute ischemic stroke patients.