RELATIONSHIP BETWEEN CD4 LEVELS AND MENSTRUAL DISORDERS IN WOMEN HIV PATIENTS AT DR SOETOMO HOSPITAL, SURABAYA

Background: HIV infection is an infection that attacks the immune system which has specific target cells that destroy CD4 T cells. Women who are infected with HIV will experience a decrease in CD4 levels which can have an impact on ovarian function where granulosa cells are the main source of ovarian reserves so this can cause menstrual cycles to be disrupted. Low CD4 levels can cause increased menstrual disorders. The aim of this study was to analyze the relationship between CD4 levels and the incidence of menstrual disorders in female HIV patients. Method:This study used a crosssectional approach with an analytic observational method. The sample used was 50 HIV-positive women according to the inclusion and exclusion criteria, then interviewed and examined CD4 levels by flow cytometry. The r-Spearman statistical test was used to determine the significance level of the data obtained at the significance level of p≤0.05. Result:The results showed a significance value of p = 0.024, which means that there was a significant positive correlation between CD4 levels and the incidence of menstrual disorders in the study subjects. The conclusion of this study is that there are 92% of HIVpositive women experiencing menstrual disorders seen from CD4 levels.