TY - JOUR
T1 - Regenerative effect of extracorporeal shockwave therapy in knee osteoarthritis patient
AU - Philothra, Petrina Theda
AU - Andriati, Andriati
AU - Subadi, Imam
AU - Wardhani, Indrayuni Lukitra
AU - Al-Hayyan, Abdul Jabbar
AU - Timor, Amandha Boy
AU - Chilmi, Mohammad Zain
AU - Melaniani, Soenarnatalina
N1 - Publisher Copyright:
© 2024 by SPC (Sami Publishing Company).
PY - 2024/5
Y1 - 2024/5
N2 - Osteoarthritis (OA) is the leading musculoskeletal disease that disrupting quality of life. ESWT has been regarded as promising noninvasive OA management. This study aims to assess how ESWT affects OA patient’s cartilage degradation using urinary C-terminal crosslinking telopeptide of type II collagen (uCTX-II) biomarker. Thirteen OA patients were selected in this one-group pretest-posttest design. Each participant received ESWT intervention once a week for six weeks. Piezo Shockwave 2 (focused-ESWT) machine with an intensity 0.27 mJ/mm2, frequency 4 mHz, and total impulse 4000 shocks was used. Cartilage degradation was evaluated by uCTX-II before therapy (T1), at three weeks (T2) and six weeks after completing serial intervention (T3). uCTX-II results improved significantly during T2 (p=0.000) and got the peak at T3 compared to before treatment (p=0.001). Repeated measure test using general linier model demonstrated significant gradual pain reduction (p=0.00). Pearson correlation test revealed that pain scale (WBS) was highly associated with uCTX-II baseline result (p=0.002, r=0.781). ESWT is an effective and safe intervention allowing knee pain reduction and improvement in OA cartilage degradation.
AB - Osteoarthritis (OA) is the leading musculoskeletal disease that disrupting quality of life. ESWT has been regarded as promising noninvasive OA management. This study aims to assess how ESWT affects OA patient’s cartilage degradation using urinary C-terminal crosslinking telopeptide of type II collagen (uCTX-II) biomarker. Thirteen OA patients were selected in this one-group pretest-posttest design. Each participant received ESWT intervention once a week for six weeks. Piezo Shockwave 2 (focused-ESWT) machine with an intensity 0.27 mJ/mm2, frequency 4 mHz, and total impulse 4000 shocks was used. Cartilage degradation was evaluated by uCTX-II before therapy (T1), at three weeks (T2) and six weeks after completing serial intervention (T3). uCTX-II results improved significantly during T2 (p=0.000) and got the peak at T3 compared to before treatment (p=0.001). Repeated measure test using general linier model demonstrated significant gradual pain reduction (p=0.00). Pearson correlation test revealed that pain scale (WBS) was highly associated with uCTX-II baseline result (p=0.002, r=0.781). ESWT is an effective and safe intervention allowing knee pain reduction and improvement in OA cartilage degradation.
KW - ESWT
KW - Osteoarthritis
KW - chronic disease
KW - rehabilitation
KW - uCTX-II
UR - http://www.scopus.com/inward/record.url?scp=85184185304&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2024.432509.1071
DO - 10.48309/jmpcr.2024.432509.1071
M3 - Article
AN - SCOPUS:85184185304
SN - 2981-0221
VL - 6
SP - 665
EP - 674
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 5
ER -