Refractive index calculation study of collagen-chitosan-sodium hyaluronate using Mach-Zehnder interferometer for artificial cornea

Novi Dwi Widya Rini, Lendy Pradhana Hartono, Prihartini Widiyanti, Siswanto, Herri Trilaksana

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Corneal damage is a major cause of blindness worldwide. As reported by Rapid Assessment of Avoidable Blindness (RAAB) in 2013, Indonesia is facing a serious problem of cornea blindness with 966.326 patients of the 2 million population. Gold standard such as keratoplasty couldn't completely heal cornea injury due to the limited number of donors. Those concerns lead to the development of artificial corneal tissue which provides corneal function as a refraction medium. This research conducted to provide initial description of Collagen (crosslinked HMPC)-Chitosan-Sodium Hyaluronate (Col/HPMC-Chi-NaHA) as artificial cornea through refractive index calculation study. Membrane was synthesized by forming 20% w/v Collagen crosslinked HMPC, 10% w/v Chitosan, and 0.6% w/v NaHA. Refractive index calculation is done using the Mach-Zehnder Interferometer (MZI). A green laser with a wavelength of 532ânm was passed over the membrane placed on a glass slide to produce a bright-dark pattern. Using optical path length difference concepts, membrane refractive index was obtained. The membrane displays desirable refractive index properties for corneal tissue engineering applications with the value of refractive index of 1.499.

Original languageEnglish
Title of host publication2nd International Conference on Physical Instrumentation and Advanced Materials 2019
EditorsHerri Trilaksana, Sulaiman Wadi Harun, Cameron Shearer, Moh Yasin
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440562
DOIs
Publication statusPublished - 9 Dec 2020
Event2nd International Conference on Physical Instrumentation and Advanced Materials, ICPIAM 2019 - Surabaya, Indonesia
Duration: 22 Oct 2019 → …

Publication series

NameAIP Conference Proceedings
Volume2314
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference2nd International Conference on Physical Instrumentation and Advanced Materials, ICPIAM 2019
Country/TerritoryIndonesia
CitySurabaya
Period22/10/19 → …

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