TY - JOUR
T1 - Reassortments among avian influenza A(H5N1) viruses circulating in Indonesia, 2015-2016
AU - Karo-Karo, Desniwaty
AU - Bodewes, Rogier
AU - Wibawa, Hendra
AU - Artika, I. Made
AU - Pribadi, Eko Sugeng
AU - Diyantoro, D.
AU - Pratomo, Widya
AU - Sugama, Agus
AU - Hendrayani, Nani
AU - Indasari, Iin
AU - Wibowo, Michael Haryadi
AU - Muljono, David Handojo
AU - Stegeman, Jan Arend
AU - Koch, Guus
N1 - Publisher Copyright:
© 2019, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
AB - Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
UR - http://www.scopus.com/inward/record.url?scp=85061965575&partnerID=8YFLogxK
U2 - 10.3201/eid2503.180167
DO - 10.3201/eid2503.180167
M3 - Article
C2 - 30789142
AN - SCOPUS:85061965575
SN - 1080-6040
VL - 25
SP - 465
EP - 472
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 3
ER -
