Quercetin Exerts a Protective Effect on Ischemic Stroke-induced Memory Deficits in Mice

Chrismawan Ardianto, Dewi Lestari, Luthfia Hany Primadani, Dwi Retno Puspitasari, I. Nengah Budi Sumartha, Khoirotin Nisak, Aniek Setiya Budiatin, Dewi Wara Shinta, Mareta Rindang Andarsari, Farida Ifadotunnikmah, Amar Daud Iskandar Abdullah, Mahardian Rahmadi, Junaidi Khotib

Research output: Contribution to journalArticlepeer-review


Objectives: Brain injury resulting from an ischemic stroke affects cognitive performance by disrupting the hippocampus. Several processes are involved in brain injury progression, including inflammation, glutamate excitotoxicity, and modulated brain peptide systems such as the melanocortin system. Reports show that quercetin exerts neuroprotective activity. This study investigates quercetin’s role in the cognitive function of ischemic stroke-induced mice and the possible mechanisms involved. Materials and Methods: ICR mice were used. The left unilateral common carotid artery occlusion was conducted for 4 h to induce an ischemic stroke in the mice. Quercetin 50, 100, and 200 mg/kg were administered to separate groups intraperitoneally for 7 days. Cognitive function was examined using the T-maze test. The hippocampal mRNA expressions of NR2A, NR2B, melanocortin 4 receptor (MC4R), pro-opiomelanocortin precursors (POMC), and nuclear factor 2 (Nrf2) were examined using reverse transcription-polymerase chain reaction. Results: It was found that stroke disrupted cognitive function. Quercetin administration ameliorated cognitive impairment. Quercetin attenuated the stroke-induced decrease in MC4R mRNA expression. Moreover, quercetin suppressed the stroke-induced increase in the hippocampal mRNA expression of NR2A. Conclusion: Quercetin ameliorates cognitive deficits and normalizes impaired hippocampal melanocortin and glutamatergic signaling in ischemic stroke-induced mice.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalJournal of Pharmacology and Pharmacotherapeutics
Issue number2
Publication statusPublished - Jun 2023


  • Brain injury
  • NMDAr
  • Nrf2
  • health
  • medicine
  • melanocortin
  • quercetin


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