TY - JOUR
T1 - Quercetin as an Anticancer Candidate for Glioblastoma Multiforme by Targeting AKT1, MMP9, ABCB1, and VEGFA
T2 - An in silico Study
AU - Widyananda, Muhammad H.
AU - Pratama, Setyaki K.
AU - Ansori, Arif N.M.
AU - Antonius, Yulanda
AU - Kharisma, Viol D.
AU - Murtadlo, Ahmad A.A.
AU - Jakhmola, Vikash
AU - Rebezov, Maksim
AU - Khayrullin, Mars
AU - Derkho, Marina
AU - Ullah, Md Emdad
AU - Susilo, Raden J.K.
AU - Hayaza, Suhailah
AU - Nugraha, Alexander P.
AU - Proboningrat, Annise
AU - Fadholly, Amaq
AU - Sibero, Mada T.
AU - Zainul, Rahadian
N1 - Publisher Copyright:
© 2023 University of Kerbala.
PY - 2023
Y1 - 2023
N2 - Quercetin, a natural compound present in various fruits and vegetables, shows promise as a potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM potential of Quercetin. The protein target of Quercetin is identified and analyzed using databases such as NCBI, SEA, CTD, and STRING. Proteineprotein interaction (PPI) and functional annotation are carried out based on the obtained target proteins. Molecular docking and dynamics simulations are employed using AutoDock Vina and WebGro tools to analyze the interaction between Quercetin and its target proteins. The prediction of protein targets reveals that Quercetin directly targets four proteins associated with GBM. In conclusion, Quercetin demonstrates potential as an anti-GBM agent, specifically by targeting AKT1, MMP9, ABCB1, and VEGFA proteins.
AB - Quercetin, a natural compound present in various fruits and vegetables, shows promise as a potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM potential of Quercetin. The protein target of Quercetin is identified and analyzed using databases such as NCBI, SEA, CTD, and STRING. Proteineprotein interaction (PPI) and functional annotation are carried out based on the obtained target proteins. Molecular docking and dynamics simulations are employed using AutoDock Vina and WebGro tools to analyze the interaction between Quercetin and its target proteins. The prediction of protein targets reveals that Quercetin directly targets four proteins associated with GBM. In conclusion, Quercetin demonstrates potential as an anti-GBM agent, specifically by targeting AKT1, MMP9, ABCB1, and VEGFA proteins.
KW - Anticancer
KW - Inhibitor
KW - Medicine
KW - Molecular dynamic
KW - Quercetin
UR - http://www.scopus.com/inward/record.url?scp=85168465438&partnerID=8YFLogxK
U2 - 10.33640/2405-609X.3312
DO - 10.33640/2405-609X.3312
M3 - Article
AN - SCOPUS:85168465438
SN - 2405-609X
VL - 9
SP - 450
EP - 459
JO - Karbala International Journal of Modern Science
JF - Karbala International Journal of Modern Science
IS - 3
ER -