Quercetin Accelerated Hipoxia Iinducible Factor-1α Expression in Tooth Sockets Wistar Rats

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All or part of an organ's function is lost, as is the sympathetic response to stress, bleeding, and blood coagulation, bacterial infection, and cell death are some of the consequences of a wound. There will be a regeneration process that involves the soft tissue and hard tissue of the oral cavity in the wound caused by tooth extraction. Quercetin is a flavonoid found in plants that has anti-oxidant and anti-inflammatory activities. It can lessen the symptoms of inflammation and improve the healing of wounds. All samples were randomly categorized into 4 groups (8 rats for each). Group 1 (quercetin 20mg/kg body weight for two days), Group 2 (control group for two days), Group 3 (quercetin 20mg/kg body weight for five days) and Group 4 (control group for five days). The outcomes on the 2nd and 5th days, while inspected using a light beam conducted to the tissue and magnified 450 times, indicate that the group received quercetin has much more HIF-1 expressing cells than the control group. Conclusion: Quercetin can potentially level up the rise of HIF-1 expression in the Wistar Rat after tooth extraction.

Original languageEnglish
Pages (from-to)1043-1045
Number of pages3
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2022


  • Bone regeneration
  • Hif-1a
  • Quercetin


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