TY - JOUR
T1 - Protein Analysis of Royal Jelly Bee Apis Mellifera Carpatica as Candidates for Immunotherapy in Reproductive Disorders
AU - Mafruchati, Maslichah
AU - Makuwia, Jonathan
N1 - Publisher Copyright:
© 2022 Phcogj.Com.
PY - 2022/7
Y1 - 2022/7
N2 - Background: The honey bee of the Apis mellifera species is the main type of bee cultivated in almost all countries in the world, including Indonesia. Honey has benefits in various aspects, including food, health, and beauty. Royal jelly is a daily food menu as a food supplement to maintain and increase health and vitality. Purpose: Analyzing the immunogenic and toxinogenic proteins of Royal jelly Apis mellifera carpatica as immunotherapy. Method: Conversion of nucleotides into amino acids. Royal jelly Apis mellifera carpatica, analysis of the three-dimensional structure of Protein of Royal jelly Apis mellifera carpatica, Analysis of Ramachandran Plots of Royal jelly Apis mellifera carpatica, Analysis of epitope and allergen proteins, Analysis of antigens and toxins. Research result: The research results found that six proteins of Royal jelly Apis mellifera carpatica were epitope, antigenic, and non-toxic. Allergens and three Royal jelly proteins, Apis mellifera carpatica, are non-allergenic. In this study, the three-dimensional structure has not been found and opens opportunities for proteomic studies of the Royal jelly Apis mellifera carpatica protein, including protein isolation. Conclusion: The findings of this study can be used as a basis for the use of immunotherapy materials against the protein Royal jelly Apis mellifera carpatica against reproductive disorders.
AB - Background: The honey bee of the Apis mellifera species is the main type of bee cultivated in almost all countries in the world, including Indonesia. Honey has benefits in various aspects, including food, health, and beauty. Royal jelly is a daily food menu as a food supplement to maintain and increase health and vitality. Purpose: Analyzing the immunogenic and toxinogenic proteins of Royal jelly Apis mellifera carpatica as immunotherapy. Method: Conversion of nucleotides into amino acids. Royal jelly Apis mellifera carpatica, analysis of the three-dimensional structure of Protein of Royal jelly Apis mellifera carpatica, Analysis of Ramachandran Plots of Royal jelly Apis mellifera carpatica, Analysis of epitope and allergen proteins, Analysis of antigens and toxins. Research result: The research results found that six proteins of Royal jelly Apis mellifera carpatica were epitope, antigenic, and non-toxic. Allergens and three Royal jelly proteins, Apis mellifera carpatica, are non-allergenic. In this study, the three-dimensional structure has not been found and opens opportunities for proteomic studies of the Royal jelly Apis mellifera carpatica protein, including protein isolation. Conclusion: The findings of this study can be used as a basis for the use of immunotherapy materials against the protein Royal jelly Apis mellifera carpatica against reproductive disorders.
KW - Analysis
KW - Apis mellifera carpatica
KW - Immunotherapy
KW - Protein
KW - Royal jelly
UR - http://www.scopus.com/inward/record.url?scp=85137633659&partnerID=8YFLogxK
U2 - 10.5530/pj.2022.14.104
DO - 10.5530/pj.2022.14.104
M3 - Article
AN - SCOPUS:85137633659
SN - 0975-3575
VL - 14
SP - 338
EP - 343
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 4
ER -