Protection against brain histopathological damage in experimental cerebral malaria models after exposure to hyperbaric oxigent

Prawesty Diah Utami, Usman Hadi, Yoes Prijatna Dachlan, Guritno Suryokusumo, R. Loeki Enggar Fitri, Varidianto Yudo

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells.

Original languageEnglish
Pages (from-to)3833-3838
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2021

Keywords

  • CD3 cells
  • Cerebral malaria
  • Endothel
  • Histopathological
  • Hyperbaric oxygen

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