TY - JOUR
T1 - Prospect of stem cells conditioned medium (secretome) in ligament and tendon healing
T2 - A systematic review
AU - Rhatomy, Sholahuddin
AU - Prasetyo, Thomas Edison
AU - Setyawan, Riky
AU - Soekarno, Noha Roshadiansyah
AU - Romaniyanto, F. N.U.
AU - Sedjati, Andi Priyo
AU - Sumarwoto, Tito
AU - Utomo, Dwikora Novembri
AU - Suroto, Heri
AU - Mahyudin, Ferdiansyah
AU - Prakoeswa, Cita Rosita Sigit
N1 - Publisher Copyright:
© 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background: Tendon or ligament tears can decrease patients' quality of life. Many therapeutic interventions are available to treat such injuries. Mesenchymal stem cells (MSCs) have been shown to be effective in treating tendon or ligament tears; however, the use of stem cell-conditioned medium (CM) requires further investigation. This review focused on the use of stem cell CM as treatment for tendon or ligament tears. Methods: A systematic literature search was performed on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, and Science Direct with the terms conditioned media or conditioned medium or secretome or microvesicle or extracellular vesicle or exosome, and tendon or ligament as the search keywords. A total of 852 articles were reviewed. Five articles were identified as relevant for this systematic review. Results: Meta-analysis could not be performed because of the high heterogeneity of the reviewed studies; however, the results of this study support a positive effect of conditioned media in tendon and ligament treatment. Conclusion: This review provides evidence of improvement in the tendon and ligament healing process with stem cell CM therapy in preclinical studies.
AB - Background: Tendon or ligament tears can decrease patients' quality of life. Many therapeutic interventions are available to treat such injuries. Mesenchymal stem cells (MSCs) have been shown to be effective in treating tendon or ligament tears; however, the use of stem cell-conditioned medium (CM) requires further investigation. This review focused on the use of stem cell CM as treatment for tendon or ligament tears. Methods: A systematic literature search was performed on PubMed (MEDLINE), OVID, EMBASE, the Cochrane Library, Scopus, Web of Science, and Science Direct with the terms conditioned media or conditioned medium or secretome or microvesicle or extracellular vesicle or exosome, and tendon or ligament as the search keywords. A total of 852 articles were reviewed. Five articles were identified as relevant for this systematic review. Results: Meta-analysis could not be performed because of the high heterogeneity of the reviewed studies; however, the results of this study support a positive effect of conditioned media in tendon and ligament treatment. Conclusion: This review provides evidence of improvement in the tendon and ligament healing process with stem cell CM therapy in preclinical studies.
KW - conditioned medium
KW - ligament
KW - secretome
KW - stem cell
KW - tendon
UR - http://www.scopus.com/inward/record.url?scp=85083556439&partnerID=8YFLogxK
U2 - 10.1002/sctm.19-0388
DO - 10.1002/sctm.19-0388
M3 - Review article
C2 - 32304180
AN - SCOPUS:85083556439
SN - 2157-6564
VL - 9
SP - 895
EP - 902
JO - Stem cells translational medicine
JF - Stem cells translational medicine
IS - 8
ER -