Prognostic Factors Affecting the Mortality of Neonates with Duodenal Obstruction at RSUD Dr. Soetomo

DIto Desdwianto, Igb Adria Hariastawa, Fendy Matulatan

Research output: Contribution to journalArticlepeer-review


Background: Duodenal obstruction is a common congenital abnormality in neonates, frequently resulting in mortality due to delayed treatment and postoperative complications. The delay in treatment often stems from suboptimal patient conditions for surgery, underscoring the critical role of laboratory examinations in guiding perioperative decisions. Objective: This study aims to investigate the relationship between preoperative laboratory parameters and mortality in neonates with duodenal obstruction. Methods: This descriptive-analytic study with a retrospective cohort design was conducted on neonates with duodenal obstruction treated at Dr. Soetomo Regional Public Hospital (RSUD Dr. Soetomo) in Surabaya from 2016 to 2023. Results: This study comprised 56 subjects, including 33 females (58.9%) and 23 males (41.1%). The p-values of the factors, in order of their influence on mortality, were as follows: platelet count (p = 0.002), hemoglobin level (p = 0.086), and age at surgery (p = 0.086). Correspondingly, the odds ratios (OR) for each factor were determined as follows: 4.048 for age at surgery, 4.259 for hemoglobin level, and 6.206 for platelet count. Platelet count demonstrated the highest accuracy value at 71.4%, with a sensitivity of 70.8% and specificity of 76.7%. Hemoglobin level exhibited an accuracy value of 67.8%, a sensitivity of 62.5%, and a specificity of 71.9%, while age at surgery showed an accuracy value of 66%, a sensitivity of 70.8%, and a specificity of 62.5%. Conclusion: In neonates with duodenal obstruction, a significant association exists between age at surgery, hemoglobin level, and platelet count with mortality. Among these factors, platelet count emerges as the most influential.

Original languageEnglish
Pages (from-to)579-589
Number of pages11
JournalJournal of Medicinal and Chemical Sciences
Issue number4
Publication statusPublished - Apr 2024


  • Duodenal obstruction
  • Neonates
  • Prognosis factors


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