TY - JOUR
T1 - Probiotic Lactobacillus plantarum IS-10506, Expression of Glial Fibrillary Acidic Protein and Platelet Endothelial Cell Adhesion Molecule-1 by Astrocytes and Endothelial Integrity
T2 - The Importance of Intestinal Microbiota as Blood Brain–Barrier Stabilizer
AU - Ranuh, Reza Gunadi
AU - Athiyyah, Alpha Fardah
AU - Darma, Andy
AU - Riawan, Wibi
AU - Gunawan, Prastiya Indra
AU - Surono, Ingrid Suryanti
AU - Sudarmo, Subijanto Marto
N1 - Publisher Copyright:
Copyright © 2022 by New Century Health Publishers, LLC
PY - 2022
Y1 - 2022
N2 - Gut microbiota is a complex community that helps maintain the dynamic metabolic ecological balance of the brain through the gut–brain axis and keeps the blood–brain barrier structure intact. However, the knowledge of how the gut microbiota responds to exogenous influences on the blood–brain barrier structure remains limited. This study hypothesizes that probiotic Lactobacillus plantarum IS 10506 supplementations could ameliorate the disruption of the blood–brain barrier structure. To this end, we examined effect of the probiotic L. plantarum IS 10506 on the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1 in the control and E. coli serotype O55:B5 lipopolysaccharide treated blood–brain barrier disruption model of Wistar rats. The rats receiving L. plantarum IS 10506 alone or along with E. coli serotype O55:B5 lipopolysaccharide exhibited upregulation of the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1. In conclusion, the probiotic L. plantarum IS-10506 stimulates the restoration of blood–brain barrier disruption.
AB - Gut microbiota is a complex community that helps maintain the dynamic metabolic ecological balance of the brain through the gut–brain axis and keeps the blood–brain barrier structure intact. However, the knowledge of how the gut microbiota responds to exogenous influences on the blood–brain barrier structure remains limited. This study hypothesizes that probiotic Lactobacillus plantarum IS 10506 supplementations could ameliorate the disruption of the blood–brain barrier structure. To this end, we examined effect of the probiotic L. plantarum IS 10506 on the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1 in the control and E. coli serotype O55:B5 lipopolysaccharide treated blood–brain barrier disruption model of Wistar rats. The rats receiving L. plantarum IS 10506 alone or along with E. coli serotype O55:B5 lipopolysaccharide exhibited upregulation of the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1. In conclusion, the probiotic L. plantarum IS-10506 stimulates the restoration of blood–brain barrier disruption.
KW - Blood–brain barrier
KW - Brain injury
KW - Glial fibrillary acidic protein
KW - Gut microbiota
KW - Lactobacillus plantarum IS-10506
KW - Platelet endothelial cell adhesion molecule-1
KW - Probiotic
UR - http://www.scopus.com/inward/record.url?scp=85128472235&partnerID=8YFLogxK
U2 - 10.37290/IJPP2641-7197.17:21-26
DO - 10.37290/IJPP2641-7197.17:21-26
M3 - Article
AN - SCOPUS:85128472235
SN - 1555-1431
VL - 17
SP - 21
EP - 26
JO - International Journal of Probiotics and Prebiotics
JF - International Journal of Probiotics and Prebiotics
IS - 1
ER -
