Gut microbiota is a complex community that helps maintain the dynamic metabolic ecological balance of the brain through the gut–brain axis and keeps the blood–brain barrier structure intact. However, the knowledge of how the gut microbiota responds to exogenous influences on the blood–brain barrier structure remains limited. This study hypothesizes that probiotic Lactobacillus plantarum IS 10506 supplementations could ameliorate the disruption of the blood–brain barrier structure. To this end, we examined effect of the probiotic L. plantarum IS 10506 on the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1 in the control and E. coli serotype O55:B5 lipopolysaccharide treated blood–brain barrier disruption model of Wistar rats. The rats receiving L. plantarum IS 10506 alone or along with E. coli serotype O55:B5 lipopolysaccharide exhibited upregulation of the expression of glial fibrillary acidic protein and platelet endothelial cell adhesion molecule-1. In conclusion, the probiotic L. plantarum IS-10506 stimulates the restoration of blood–brain barrier disruption.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalInternational Journal of Probiotics and Prebiotics
Issue number1
Publication statusPublished - 2022


  • Blood–brain barrier
  • Brain injury
  • Glial fibrillary acidic protein
  • Gut microbiota
  • Lactobacillus plantarum IS-10506
  • Platelet endothelial cell adhesion molecule-1
  • Probiotic


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