Prevalence and antimicrobial resistance profiles of multidrug-resistant bacterial isolates from urinary tract infections in Indonesian patients: A cross-sectional study

Muhammad E. Prastiyanto, Arya Iswara, Afifah Khairunnisa, Fajar Sofyantoro, Abdul R. Siregar, Wulan U. Mafiroh, Jajar Setiawan, Fitri Nadifah, Anjar T. Wibowo, Wahyu A. Putri

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Abstract

This study aimed to determine the prevalence of multidrug-resistant (MDR) bacterial isolates in urinary tract infections (UTI) patients in Indonesia, where access to appropriate antibiotic treatment may be limited. A cross-sectional study was conducted from January 2020 to December 2022, with 308 bacterial isolates from UTIs cultured and tested for antimicrobial susceptibility. The most identified bacterial isolate was Escherichia coli (39.6 %), followed by Klebsiella pneumoniae (11.6 %) and Staphylococcus spp. (11.03 %). The overall prevalence of MDR bacterial isolates was 35 %, with the highest resistance observed to ampicillin (60 %) and cotrimoxazole (50 %). Independent risk factors for the development of MDR UTIs included age (p = 0.03) and male sex (p = 0.02). These findings underscore the need for ongoing monitoring of antibiotic resistance patterns and the development of antimicrobial stewardship programs to address this public health issue in Indonesia.

Original languageEnglish
Article number100359
JournalClinical Infection in Practice
Volume22
DOIs
Publication statusPublished - Apr 2024

Keywords

  • Antibiotic
  • Health risk
  • Indonesia
  • Multi-drug resistance
  • Urinary tract infections

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