TY - JOUR
T1 - Preconditioning of hypoxic culture increases the therapeutic potential of adipose derived mesenchymal stem cells
AU - Sumarwoto, Tito
AU - Suroto, Heri
AU - Mahyudin, Ferdiansyah
AU - Utomo, Dwikora Novembri
AU - Romaniyanto,
AU - Prijosedjati, Andhi
AU - Utomo, Pamudji
AU - Prakoeswa, Cita Rosita Sigit
AU - Rantam, Fedik Abdul
AU - Tinduh, Damayanti
AU - Notobroto, Hari Basuki
AU - Rhatomy, Sholahuddin
N1 - Publisher Copyright:
© 2021 Tito Sumarwoto, Heri Suroto, Ferdiansyah Mahyudin, Dwikora Novembri Utomo, Romaniyanto, Andhi Prijosedjati, Pamudji Utomo, Cita Rosita Sigit Prakoeswa, Fedik Abdul Rantam, Damayanti Tinduh, Hari Basuki Notobroto, Sholahuddin Rhatomy.
PY - 2021/1/10
Y1 - 2021/1/10
N2 - Stem cell-based therapy is one of the most promising strategies in promoting tissue regeneration. Mesenchymal stem cells (MSCs) derived from adipose are widely used as a source of stem cells. However, most donor stem cells die before their regenerative effects appear. Thereby, various strategies are carried out to enhance the therapeutic potential. It is hoped that the survival, engraftment, and function of implanted MSCs by preconditioning the cells will be improved. In vitro preconditioning strategies can improve the survival, engraftment, and paracrine properties of MSCs, thus optimize their reparative and regenerative capacities. One such attempt is to propagate these stem cells in a hypoxic environment, which mimics the natural tissue oxygen environment. Hypoxia preconditioning represents a comprehensive increase in regenerative gene expression in stem cell therapy. There are significant advantages in stem cell therapy with hypoxia preconditioning.
AB - Stem cell-based therapy is one of the most promising strategies in promoting tissue regeneration. Mesenchymal stem cells (MSCs) derived from adipose are widely used as a source of stem cells. However, most donor stem cells die before their regenerative effects appear. Thereby, various strategies are carried out to enhance the therapeutic potential. It is hoped that the survival, engraftment, and function of implanted MSCs by preconditioning the cells will be improved. In vitro preconditioning strategies can improve the survival, engraftment, and paracrine properties of MSCs, thus optimize their reparative and regenerative capacities. One such attempt is to propagate these stem cells in a hypoxic environment, which mimics the natural tissue oxygen environment. Hypoxia preconditioning represents a comprehensive increase in regenerative gene expression in stem cell therapy. There are significant advantages in stem cell therapy with hypoxia preconditioning.
KW - Adipose Derived Mesenchymal Stem Cells
KW - Culture
KW - Hypoxic
UR - http://www.scopus.com/inward/record.url?scp=85118561321&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2021.5870
DO - 10.3889/oamjms.2021.5870
M3 - Article
AN - SCOPUS:85118561321
SN - 1857-5749
VL - 9
SP - 505
EP - 515
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
ER -