TY - JOUR
T1 - Potential of Solanum betaceum to improve cognition
T2 - A systematic review of animal studies
AU - Imania, Hana Aqilah Nur
AU - Rachma, Aida Fahira
AU - Kurniawati, Lady Aqnes
AU - Hidayati, Hanik Badriyah
AU - Wungu, Citrawati Dyah Kencono
AU - Nazmuddin, Muhammad
N1 - Publisher Copyright:
© 2024 Journal of Pharmacy & Pharmacognosy Research.
PY - 2024/1
Y1 - 2024/1
N2 - Context: Solanum betaceum is rich in bioactive compounds associated with various health applications, including plausible benefits on cognitive impairment caused by neurodegenerative diseases such as Alzheimer’s disease (AD). Aims: To investigate the potential benefit of consuming S. betaceum to alleviate cognitive and memory decline. Methods: The review was conducted as a systematic review of an in vivo animal study. A search was performed of five databases using the keywords: “solanum betaceum”, “S. betaceum”, “tamarillo”, “neurodegenerative diseases”, “memory loss”, “cognitive impairment”. SYRCLE tool was used to assess the risk of bias. Data on the underlying molecular mechanisms of behavioral efficacy was additionally collected. Results: A total of 66 journals were retrieved from the databases, resulting in 3 eligible studies. All included studies used albino rats as an AD animal model that were accustomed to laboratory conditions for about a week prior to the disease induction. In two studies, aluminum chloride (AlCl3) was utilized to induce memory deficit, while another study used cigarette smoke. The result indicated that S. betaceum contained compounds such as phenolic and anthocyanin, which were plausibly responsible for the positive cognitive outcomes through molecular interaction with intracellular signaling protein cascades associated with anti-inflammation, brain oxygenation, synaptic plasticity, and cell viability. Further preclinical studies are needed to confirm these potentials. Conclusions: This systematic review of the current evidence on the behavioral and biological influences of S. betaceum administration on AD animal models pointed out that the fruit might improve cognitive performance and prevent cognitive deterioration raised by several neurotoxins.
AB - Context: Solanum betaceum is rich in bioactive compounds associated with various health applications, including plausible benefits on cognitive impairment caused by neurodegenerative diseases such as Alzheimer’s disease (AD). Aims: To investigate the potential benefit of consuming S. betaceum to alleviate cognitive and memory decline. Methods: The review was conducted as a systematic review of an in vivo animal study. A search was performed of five databases using the keywords: “solanum betaceum”, “S. betaceum”, “tamarillo”, “neurodegenerative diseases”, “memory loss”, “cognitive impairment”. SYRCLE tool was used to assess the risk of bias. Data on the underlying molecular mechanisms of behavioral efficacy was additionally collected. Results: A total of 66 journals were retrieved from the databases, resulting in 3 eligible studies. All included studies used albino rats as an AD animal model that were accustomed to laboratory conditions for about a week prior to the disease induction. In two studies, aluminum chloride (AlCl3) was utilized to induce memory deficit, while another study used cigarette smoke. The result indicated that S. betaceum contained compounds such as phenolic and anthocyanin, which were plausibly responsible for the positive cognitive outcomes through molecular interaction with intracellular signaling protein cascades associated with anti-inflammation, brain oxygenation, synaptic plasticity, and cell viability. Further preclinical studies are needed to confirm these potentials. Conclusions: This systematic review of the current evidence on the behavioral and biological influences of S. betaceum administration on AD animal models pointed out that the fruit might improve cognitive performance and prevent cognitive deterioration raised by several neurotoxins.
KW - Alzheimer’s disease
KW - Solanum
KW - antioxidants
KW - cognition
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85185169136&partnerID=8YFLogxK
U2 - 10.56499/jppres23.1729_12.1.1
DO - 10.56499/jppres23.1729_12.1.1
M3 - Review article
AN - SCOPUS:85185169136
SN - 0719-4250
VL - 12
SP - 1
EP - 13
JO - Journal of Pharmacy and Pharmacognosy Research
JF - Journal of Pharmacy and Pharmacognosy Research
IS - 1
ER -