Potential of Moringa oleifera Leaf Extract on IL -8 Expression in Benzo(a)pyrene-Induced-Oral Cancer of Rattus norvegicus

Introduction: Cancer is a disease caused by abnormal growth and uncontrolled cells. Moringa leaf extract can prevent or destroy tumors and cancer cells because it contains benzyl isothiocyanate. Many scientific studies have shown that these chemicals have anti-cancer and chemoprotective capabilities. IL-8 is a chemotactic factor expressed in endothelial cells. This study aims to know the potential of Moringa leaf extract as anti-angiogenesis of oral cancer by IL-8 expression in rats induced by benzo(a)pyrene. Material and methods: This research was an experimental laboratory with a post-test only control group design divided into four groups, control group (K) and a treatment group was given Moringa extract with a dose of 20mg/kg/BW, 40mg/kg/BW, 80mg/kg/BW. Immunohistochemical analysis was used to determine IL-8 expression. Result: ANOVA data analysis revealed that group treatment with 40mg/kg/BW has the lowest number of IL-8 expression in endothelial cells of rats induced by benzo(a)pyrene. Conclusion: Moringa oleifera extract with a dose of 40 mg/kg/BW is the best dose that can inhibit angiogenesis of oral cancer cells in male rats (Rattus norvegicus) induced benzo(a)pyrene.