Background: Hyperglycemia can cause adverse effects in the oral cavity, one of which is inhibiting wound healing. Chronic hyperglycemia reduces the expression and distribution of growth factors, such as fibroblast growth factor-2 (FGF-2), a significant growth factor in angiogenesis. The disruption of wound healing may lead to chronic wounds to further infection. Routine oral wound treatment using topical steroid ointment is considered ineffective in hyperglycemic individuals due to its anti-angiogenic properties. Anadara granosa shell nanoparticles can induce the production of numerous growth factors such as FGF-2 and augment angiogenesis. Objective: To determine the potential of giving Anadara granosa shell nanoparticles to increase FGF-2 in chronic inflammatory wounds with hyperglycemia conditions. Discussion: Angiogenesis supports and intersects with other ongoing proliferative activities and with the remodeling phase. FGF-2 helps the proliferation of endothelial cells and the arrangement of endothelial cells to form a tube to help angiogenesis. Hyperglycemia is directly associated with a significant reduction in FGF-2-induced angiogenesis in vivo. Biogenic CaCO3 nanoparticles made from Anadara granosa have shown promising potential to increase FGF-2 by activating NF-κB signaling. Conclusion: Anadara granosa shell nanoparticles have the potential to increase the expression of fibroblast growth factor-2 (FGF-2) in chronic inflammatory wounds with hyperglycemia conditions.
- Anadara granosa shell nanoparticles
- chronic inflammatory wounds
- fibroblast growth factor-2
- wound healing