TY - JOUR
T1 - Potential misdiagnosis between COVID-19 and dengue infection using rapid serological test
AU - Khairunisa, Siti Qamariyah
AU - Amarullah, Ilham Harlan
AU - Churrotin, Siti
AU - Fitria, Anisa Lailatul
AU - Amin, Mochammad
AU - Lusida, Maria Inge
AU - Soegijanto, Soegeng
N1 - Funding Information:
Funding: The present study was supported by the Grant-in-Aid from Universitas Airlangga (Hibah Khusus Riset Mandat COVID-19 Grant No.1093/UN3.14/PT/2020).
Funding Information:
Acknowledgments: The present study was supported by the Center of Excellence (COE) program by the Indonesian Ministry for Research and Technology.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/).
PY - 2021/6
Y1 - 2021/6
N2 - The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 and dengue in the early incubation period, and thus discerning the infection is difficult. As a dengue-endemic country, Indonesia also poses the same challenge during the COVID-19 outbreak. This current study analyzed the IgG and IgM profiles from COVID-19 patients by using a serological SARS-CoV-2 and dengue rapid test. In addition, 38 sera from healthy individuals (pre-COVID-19 date) were analyzed using a dengue rapid test. Among 120 samples, 4 samples indicated dengue IgG positive. However, IgM, NS1, and RT-PCR analyses showed negative results. Interestingly, regarding seropositivity of NS1 and DENV IgG from healthy individuals (pre COVID-19 infection), two samples were positive DENV IgG, while one of them was positive NS1. This suggested that in the dengue-endemic area, many people have already experienced dengue and have immunity against dengue virus. There is also the possibility of antibody cross-reactivity between COVID-19 and dengue infection. This also emphasizes the high demand for a rapid method with high sensitivity and specificity that can distinguish between SARS-CoV-2 and dengue.
AB - The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 and dengue in the early incubation period, and thus discerning the infection is difficult. As a dengue-endemic country, Indonesia also poses the same challenge during the COVID-19 outbreak. This current study analyzed the IgG and IgM profiles from COVID-19 patients by using a serological SARS-CoV-2 and dengue rapid test. In addition, 38 sera from healthy individuals (pre-COVID-19 date) were analyzed using a dengue rapid test. Among 120 samples, 4 samples indicated dengue IgG positive. However, IgM, NS1, and RT-PCR analyses showed negative results. Interestingly, regarding seropositivity of NS1 and DENV IgG from healthy individuals (pre COVID-19 infection), two samples were positive DENV IgG, while one of them was positive NS1. This suggested that in the dengue-endemic area, many people have already experienced dengue and have immunity against dengue virus. There is also the possibility of antibody cross-reactivity between COVID-19 and dengue infection. This also emphasizes the high demand for a rapid method with high sensitivity and specificity that can distinguish between SARS-CoV-2 and dengue.
KW - COVID-19
KW - Cross-reactivity
KW - Dengue
KW - Rapid serological test
KW - Sars-Cov 2
UR - http://www.scopus.com/inward/record.url?scp=85107913813&partnerID=8YFLogxK
U2 - 10.3390/idr13020050
DO - 10.3390/idr13020050
M3 - Article
AN - SCOPUS:85107913813
SN - 2036-7430
VL - 13
SP - 540
EP - 551
JO - Infectious Disease Reports
JF - Infectious Disease Reports
IS - 2
ER -
