Potential effect of Raw Honey on Gastric Mucosal Healing in Aspirin-induced Rats

Devyani Diah Wulansari, Aguslina Kirtishanti, Reine Risa Risthanti, Devyana Dyah Wulandari, Lili Soetjipto, Dwi Winarni

Research output: Contribution to journalArticlepeer-review


Background: Raw honey is a natural ingredient which has a variety of nutrients that can be used for alternative treatments for peptic ulcer disease. This study was carried out to examine the antiulcer effects of Raw Honey against Aspirin induced gastritis in rats. Methodology: Wistar rats were separated into 6 groups. Aspirin suspension 200mg/kgBW was given orally to groups 2-6 for 2 days. Then, group 1 and 2 received carboxymethylcellulose (CMC), groups 3-5 were orally forced-fed with 3.5, 7, and 14mL/kgBW of raw honey, and group 6 received 100mg/kgBW Cimetidine. The tested animals were killed after receiving therapy for 15 days and the gastric mucosa was observed macroscopically of the ulcer index and microscopically through histopathological preparations. The antioxidant effect of raw honey was identified from the lipid peroxidation marker (MDA). Conclusion : Treatment with 7 and 14 ml/kgBW of raw honey promotes gastric mucosal repair based on the macroscopic and microscopic observations. Significant decreases in the levels of the lipid peroxidation marker (MDA) was observed. Significance was defined as p<0.05 compared to the ulcer control group (Group 6).

Original languageEnglish
Pages (from-to)1153-1160
Number of pages8
JournalResearch Journal of Pharmacy and Technology
Issue number3
Publication statusPublished - Mar 2023


  • Antiulcer
  • Aspirin
  • Gastrtitis
  • Malonedialdehyde
  • Raw honey
  • Total cidity


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