Polymorphisms of HLA genes in Western Javanese (Indonesia) and their association to tuberculosis

Rika Yuliwulandari, Tripanjiasih Susmiarsih, Kouichi Kashiwase, Fumiaki Nakajima, Helmia Hasan, Yulino Amrie, Katsushi Tokunaga

Research output: Contribution to journalArticlepeer-review


Human Leukocyte Antigen (HLA) genes diversity has been studied in Western Javanese (Indonesia) and their role in susceptibility to tuberculosis (TB) was examined. HLA-A, -B and -DRB1 were genotyped in 237 unrelated healthy Western Javanese (Indonesia) and 216 PTB patients by the high-resolution polymerase chain reaction-Luminex method. The most frequently detected alleles at the serological level were HLA-A24 (f=0.69), -B15 (f=0.68), and -DR12 (f=0.59). The phylogenetic tree analysis showed that Western Javanese (Indonesia) was closest to Southeast Asian populations. Based on the allele positivity, HLA-DR4 and -DR13 showed a weak association to PTB (p = 0.01 pc = ns and p = 0.03 pc = ns, respectively). This study suggests that HLA genes do not strongly contribute to the development of PTB in Western Javanese population.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
Issue number3
Publication statusPublished - 2010


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