Polymorphisms of HLA genes in Western Javanese (Indonesia) and their association to tuberculosis

Rika Yuliwulandari; Tripanjiasih Susmiarsih; Kouichi Kashiwase; Fumiaki Nakajima; Helmia Hasan; Yulino Amrie; Katsushi Tokunaga

Polymorphisms of HLA genes in Western Javanese (Indonesia) and their association to tuberculosis

Rika Yuliwulandari, Tripanjiasih Susmiarsih, Kouichi Kashiwase, Fumiaki Nakajima, Helmia Hasan, Yulino Amrie, Katsushi Tokunaga

Research output: Contribution to journal › Article › peer-review

Abstract

Human Leukocyte Antigen (HLA) genes diversity has been studied in Western Javanese (Indonesia) and their role in susceptibility to tuberculosis (TB) was examined. HLA-A, -B and -DRB1 were genotyped in 237 unrelated healthy Western Javanese (Indonesia) and 216 PTB patients by the high-resolution polymerase chain reaction-Luminex method. The most frequently detected alleles at the serological level were HLA-A24 (f=0.69), -B15 (f=0.68), and -DR12 (f=0.59). The phylogenetic tree analysis showed that Western Javanese (Indonesia) was closest to Southeast Asian populations. Based on the allele positivity, HLA-DR4 and -DR13 showed a weak association to PTB (p = 0.01 pc = ns and p = 0.03 pc = ns, respectively). This study suggests that HLA genes do not strongly contribute to the development of PTB in Western Javanese population.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Kekkaku
Volume	85
Issue number	3
Publication status	Published - 2010

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title = "Polymorphisms of HLA genes in Western Javanese (Indonesia) and their association to tuberculosis",

abstract = "Human Leukocyte Antigen (HLA) genes diversity has been studied in Western Javanese (Indonesia) and their role in susceptibility to tuberculosis (TB) was examined. HLA-A, -B and -DRB1 were genotyped in 237 unrelated healthy Western Javanese (Indonesia) and 216 PTB patients by the high-resolution polymerase chain reaction-Luminex method. The most frequently detected alleles at the serological level were HLA-A24 (f=0.69), -B15 (f=0.68), and -DR12 (f=0.59). The phylogenetic tree analysis showed that Western Javanese (Indonesia) was closest to Southeast Asian populations. Based on the allele positivity, HLA-DR4 and -DR13 showed a weak association to PTB (p = 0.01 pc = ns and p = 0.03 pc = ns, respectively). This study suggests that HLA genes do not strongly contribute to the development of PTB in Western Javanese population.",

author = "Rika Yuliwulandari and Tripanjiasih Susmiarsih and Kouichi Kashiwase and Fumiaki Nakajima and Helmia Hasan and Yulino Amrie and Katsushi Tokunaga",

year = "2010",

language = "English",

volume = "85",

pages = "164--167",

journal = "Kekkaku",

issn = "0022-9776",

publisher = "Japanese Society for Tuberculosis",

number = "3",

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TY - JOUR

T1 - Polymorphisms of HLA genes in Western Javanese (Indonesia) and their association to tuberculosis

AU - Yuliwulandari, Rika

AU - Susmiarsih, Tripanjiasih

AU - Kashiwase, Kouichi

AU - Nakajima, Fumiaki

AU - Hasan, Helmia

AU - Amrie, Yulino

AU - Tokunaga, Katsushi

PY - 2010

Y1 - 2010

N2 - Human Leukocyte Antigen (HLA) genes diversity has been studied in Western Javanese (Indonesia) and their role in susceptibility to tuberculosis (TB) was examined. HLA-A, -B and -DRB1 were genotyped in 237 unrelated healthy Western Javanese (Indonesia) and 216 PTB patients by the high-resolution polymerase chain reaction-Luminex method. The most frequently detected alleles at the serological level were HLA-A24 (f=0.69), -B15 (f=0.68), and -DR12 (f=0.59). The phylogenetic tree analysis showed that Western Javanese (Indonesia) was closest to Southeast Asian populations. Based on the allele positivity, HLA-DR4 and -DR13 showed a weak association to PTB (p = 0.01 pc = ns and p = 0.03 pc = ns, respectively). This study suggests that HLA genes do not strongly contribute to the development of PTB in Western Javanese population.

AB - Human Leukocyte Antigen (HLA) genes diversity has been studied in Western Javanese (Indonesia) and their role in susceptibility to tuberculosis (TB) was examined. HLA-A, -B and -DRB1 were genotyped in 237 unrelated healthy Western Javanese (Indonesia) and 216 PTB patients by the high-resolution polymerase chain reaction-Luminex method. The most frequently detected alleles at the serological level were HLA-A24 (f=0.69), -B15 (f=0.68), and -DR12 (f=0.59). The phylogenetic tree analysis showed that Western Javanese (Indonesia) was closest to Southeast Asian populations. Based on the allele positivity, HLA-DR4 and -DR13 showed a weak association to PTB (p = 0.01 pc = ns and p = 0.03 pc = ns, respectively). This study suggests that HLA genes do not strongly contribute to the development of PTB in Western Javanese population.

UR - http://www.scopus.com/inward/record.url?scp=84861917879&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84861917879

SN - 0022-9776

VL - 85

SP - 164

EP - 167

JO - Kekkaku

JF - Kekkaku

IS - 3

ER -

Polymorphisms of HLA genes in Western Javanese (Indonesia) and their association to tuberculosis

Abstract

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