Poly(ethylene glycol)dimethacrylate - Nanofibrillated cellulose bionanocomposites as injectable hydrogel for therapy of herniated nucleus pulposus patients

Prihartini Widiyanti, Mochamad Arsyal Amali, Aminatun

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The highest disease caused by low back pain is herniated nucleus pulposus (HNP) where nucleus pulposus (NP) protrudes out through the annulus fibrosis. Injectable hydrogel is a method to restore NP function with minimal invasive surgery. Variation concentration of NFC were studied in detail toward affects on PEGDMA (poly(ethylene glycol)dimethacrylate):NFC hydrogel mechanically and injectability. The characteristics of PEGDMA and nanofibrillated cellulose (NFC) based injectable hydrogels through the photoinitiator Irgacure 2959 in the formation of hydrogels with variations composition 1:0; 1:0.25; 1:0.5; 1:0.75. In the morphological test on NFC a fibre with a diameter of 100 nm was formed from the results of electrospinning on ethyl cellulose (EC). The FTIR showed of photopolymerization of the conjugation bond between Irgacure 2959 and PEGDMA producing C-C at a frequency of 1349.20 cm-1. Swelling test used phosphate buffer saline (PBS) fulfilled the standard at a variation of 1:0.25; 1:0.5; and 1:0.75, 87.07%, 84.84% and 80.42% respectively. Viscosity test in the injectability of hydrogels showed a result of 73.67 dPa.s. The compressive strength test obtained good results in samples 1:0.75 showed a result of 3.42 kPa. In vitro injection model showed increasing of NFC concentration indicates the gel state when released from agarose will be less rupture. PEGDMA/NFC hydrogel biocomposite has the potential to be applied as an injectable hydrogel for the treatment of HNP patients based on the results.

Original languageEnglish
Pages (from-to)12716-12722
Number of pages7
JournalJournal of Materials Research and Technology
Volume9
Issue number6
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Injectable hydrogel
  • Nano-fibrillated cellulose
  • Photopolymerization
  • Poly(ethylene glycol)dimethacrylate

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