Poly (1,8 Octanediol-co-Citrate) Hydroxyapatite Composite as Antibacterial Biodegradable Bone Screw

P. Widiyanti, I. Sholikhah, A. Isfandiary, N. A.F. Hasbiyani, M. B. Lazuardi, R. D. Laksana

Research output: Contribution to journalConference articlepeer-review

5 Citations (Scopus)


The high bone fracture rates reaching up to 300-400 cases per month have been treated with surgical procedure of internal fixation. Nevertheless, the commonly used metal screw has shown several weaknesses. Therefore, it is required bone screw of which primary characteristics include being biocompatible, bio-functional, biodegradable, and anticorrosive. The study aimed to synthesize Antibacterial Poly 1,8-Octanediol-co-Citrate (POC) and investigated the effect of chitosan on the antibacterial and compatibility characteristics of POC-HA composite as antibacterial biodegradable bone screw. The characterization were conducted on POC-HA composite to assess its functional cluster, antibacterial activity, cytotoxicity, degradation capacity, and morphology. Pre-polymer POC was composited with 62% nano-HA, followed by post-polymerization treatment. The sample then coated by chitosan with composition variations of 1%, 3%, and 5%. The nano-HA marked with the appearance of phosphate cluster on the wavenumber of 872.17 cm-1 and 559.51 cm-1, while the chitosan marked with C=O stretch cluster of esther at 1729 cm-1 from Fourier Transform Infra-Red (FTIR) measurement. The best result was obtained with 3% chitosan coating. The POC-HA composites showed bacterial inhibiting ability of 16.92 mm with non-toxic characteristics. These results indicated that chitosan coating Poly 1,8-Octanediol-co-Citrate (POC)-Nano Hydroxyapatite composite is a potential candidate for an antibacterial biodegradable bone screw.

Original languageEnglish
Article number012082
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 31 May 2017
Event4th International Conference on Advanced Materials Science and Technology 2016, ICAMST 2016 - Malang, Indonesia
Duration: 27 Sept 201628 Sept 2016


  • Poly-1,8-octanediol-co-citrate (POC)
  • antibacterial biodegradable bone screw
  • chitosan
  • condensation polymerization
  • hydroxyapatite
  • nanomaterial


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